Gattefossé

Abstract Lipid-based formulations (LBFs) offer a promising strategy to enhance the oral bioavailability of poorly water-soluble drugs, such as biopharmaceutical...

Abstract Curcumin has considerable therapeutic potential; however, its poor solubility and permeability limit its clinical applications. We evaluated menthol-based hydrophobic...

Abstract This study presents a Quality by Design (QbD) strategy combined with Design of Experiments (DoE) to develop hybrid polymer–lipid hot-melt extruded (HME) formulations...

Abstract Ellagitannins (ETs) from Punica granatum leaves are susceptible to degradation under less acidic pH conditions, which may compromise their use as...

Abstract Madecassoside, a major triterpenoid glycoside from Centella asiatica, has potential value for dermatological applications; however, its poor stratum corneum permeability...

Abstract Sorafenib is an orally administered multikinase inhibitor whose clinical utility is limited by extremely low aqueous solubility and poor...

Abstract Glioblastoma is one of the aggressive and hard-to-treat forms of brain tumor, and this is largely due to the...

Abstract Liquisolid systems (LSS) represent a promising approach for improving dissolution of poorly water-soluble drugs; however, the interplay between formulation...

Abstract Poor aqueous solubility limits the in vitro dissolution performance of many drugs, among them curcumin which is a bioactive...

This year CPHI Europe opens its doors in Milan at Fiera Milano. From 6th to 8th October you can have a...