Glatt

The patent WO2019123269A1, titled “Packaged modified release gamma-hydroxybutyrate formulations having improved stability“ presents innovative formulations and packaging methods designed to enhance the dissolution and chemical stability of gamma-hydroxybutyrate (GHB), a treatment for narcolepsy.…
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The patent application 20240316057 focuses on a pulsatile release formulation for caffeine, designed to control its release profile over a specific time frame. The formulation is targeted at therapeutic and non-therapeutic uses — enhancing mental alertness and addressing conditions like morning…
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Abstract Background: Active pharmaceutical ingredient (API) content is a critical quality attribute (CQA) of amorphous solid dispersions (ASDs) prepared by spraying a solution of APIs and polymers onto the excipients in fluid bed granulator. This study presents four methods for quantifying API…
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This year´s CPHI Europe happend last week from 8th to 10th October  in Milano at Fiera Milano. . Pharma Excipients visited the excipients hall, hall 6 for you and in the following you find a broad range of booth photos as well as short introduction videos we recorded at CPhI 2024 in Milan. Here…
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This poster was presented at the EuPFI 2024 in Rotterdam by Glatt Pharmaceutical Services: Introduction ➢Bitter tasting active pharmaceutical ingredients (API) for children require effective taste masking. ➢ Pellets are ideal dosage forms: A pre-defined dose of API can be applied by…
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This year CPHI Europe opens its doors in Milano at Fiera Milano. From 8th to 10th October you can have a face-to-face chat with visitors and exhibitors again. As usual, InnoPack, P-MEC, FDF, ICSE, MedTech and BioProduction will be held together with CPHI. Pharma Excipients gives you an overview…
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Abstract Compaction pressure can induce an undesirable solid-state polymorphic transition in drugs, fragmentation, loss of coated pellet integrity, and the decreased viability and vitality of microorganisms. Thus, the excipients with increased plasticity can be considered as an option to decrease…
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Abstract The hybrid modeling strategy which is based on the integration of mechanistic and data-driven models is proposed and applied on fluidized bed granulation processes. The tight combination of empirical process knowledge by means of a mechanistic model and the multivariate data from PAT…
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Abstract The bitter drug, warfarin, has a narrow therapeutic index (NTI) and is used in paediatrics and geriatrics. The aim of this feasibility study was to formulate the taste-masked warfarin-containing pellets to be applicable for dose personalisation and to improve patient compliance, as well as…
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An industrial case study of attempting to comply with EU regulation 2022/63 Recently, concerns have been raised about the safety of titanium dioxide (TiO2), a commonly used component of pharmaceutical film coatings. The European Union has recently prohibited the application of this material in the…
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