Glatt

Plant-based functional ingredients behave differently than manufacturers of nutraceuticals and cosmetic products would like. Innovative processes such as double microencapsulation can help them to overcome bioavailability and solubility challenges. Among the currently trending functional…
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Older adults represent the major target population for oral medications, due to the high prevalence of multimorbidity. To allow for successful pharmacological treatments, patients need to adhere to their medication and, thus, patient-centric drug products with a high level of acceptability by the…
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Poster presented at 4th European Conference on Pharmaceutics 20-21 March 2023 | Marseille, France: Drug loaded pellets were produced by using the ProCell® lab system technology. The aim was to produce highly drug loaded matrix pellets with an API-polymer ratio of approximately 95:5 by using…
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The administration of living microorganisms is of special interest, with regard to probiotic microorganisms providing health benefits to the patient. Effective dosage forms require the preservation of microbial viability until administration. Storage stability can be improved by drying, and the…
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Spray drying is one of the most frequently used solvent-based processes for manufacturing amorphous solid dispersions (ASDs). However, the resulting fine powders usually require further downstream processing when intended for solid oral dosage forms. In this study, we compare properties and…
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Foam granulation (FG) is a non-conventional technique in which a binding solution is sprayed as aqueous foam. The main objectives of this work are, converting a lab-scale fluidized bed dryer into a fluidized bed foam granulator and dryer. Second, developing a partial least squares regression model…
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The aim of this work was to identify and collate the major common challenges that arise during pellet development. These challenges focus on aspects right from raw material properties until the final drying process of the pelletization. The challenges associated with the particle size of drug and…
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By Dr. Annette Grave - Glatt Pharmaceutical Services Fluid bed processes were first developed for the chemical industry to achieve better drying efficiencies than obtained with existing technologies e. g with tray drying. Implementation of spray nozzles in the fluid bed equipment enabled…
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Manufacturing tablets is frequently a multi-step process: weighing, granulation, milling, blending, compression, coating. The efforts to provide a safe work environment for the production staff are considerably reduced when a technology platform like pellets is applied for high potent APIs.…
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Among the currently trending functional ingredients, interest in natural sources such as turmeric and its polyphenol, curcumin, has been increasing for years. The spice is not only in demand in the culinary world, but has also found great promise in both consumer and scientific applications.1 …
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