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Development and application of control concepts for twin-screw wet granulation in the ConsiGma-25:…
Abstract
Traditional operation modes, such as running the production processes at constant process settings or within a narrow design space, do not fully exploit the advantages of continuous pharmaceutical manufacturing. Integrating Quality by Control (QbC) algorithms as a standard component of…
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Polymeric microspheres redefining the landscape of colon-targeted delivery: A contemporary update
Abstract
During recent times, the delivery of the medications to the colon has seen more interest by the researchers, as it proved to be providing both options for treating local colon-related conditions and a route for systemic delivery of the various other types of medications. For these to…
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Novel fast dissolving freeze dried sublingual baicalin tablets for enhanced hepatoprotective effect:…
Baicalin (BG), a natural product, has been used in the prevention and treatment of drug-induced liver injury (DILI); however, its poor solubility and extensive liver metabolism limit its pharmacological use. The aim of the present study was the formulation of fast-dissolving freeze-dried sublingual…
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Colon Drug Delivery Systems Based on Swellable and Microbially Degradable High-Methoxyl Pectin:…
Abstract
Oral colon delivery systems based on a dual targeting strategy, harnessing time- and microbiota-dependent release mechanisms, were designed in the form of a drug-containing core, a swellable/biodegradable polysaccharide inner layer and a gastroresistant outer film. High-methoxyl pectin was…
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Excipient Reactivity and Drug Stability in Formulations
This is about the excipient used for achieving sustained release function undergone chemical reaction with the stabilizing agent used for the drug product leading to product quality failure from the desired dissolution behavior. The generic version of Bupropion HCl SR 150 mg, i.e. sustained (12…
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3D Printing Direct Powder Extrusion in the Production of Drug Delivery Systems: State of the Art and…
Abstract
The production of tailored, on-demand drug delivery systems has gained attention in pharmaceutical development over the last few years, thanks to the application of 3D printing technology in the pharmaceutical field. Recently, direct powder extrusion (DPE) has emerged among the…
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Self-microemulsifying drug delivery system as carrier for the oral delivery of glimepiride:…
Abstract
Aim: The research aimed to design the glimepiride self-micro emulsifying drug delivery system (SMEDDS) for increased oral bioavailability in albino mice by assessing hypoglycemic efficacy.
Materials and Methods: The optimized liquid SMEDDS (L-SMEDDS) prepared by emulsification of…
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Colon-targeted 3D-Printed mesalamine tablets: Core-shell design and in vitro/ex-vivo evaluation
Abstract
Objectives
The present study is intended to develop a shell-core tablet using a hot melt extrusion (HME)-based dual-nozzle fused deposition modeling (FDM) three-dimensional (3D) printing approach. The primary objective was to establish a sustained-release colonic drug delivery system…
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Fabrication of 3D-Printed Hydrocortisone Triple Pulsatile Tablet Using Fused Deposition Modelling…
Hydrocortisone (HC) is the optimal drug for adolescents diagnosed with congenital adrenal hyperplasia (CAH). Because traditional dosage regimens HC are inconvenient, our study used fused deposition modeling (FDM) three-dimensional (3D) printing technology to solve the problems caused by traditional…
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A strategy to optimize precompression pressure for tablet manufacturing based on in-die elastic…
A precompression pressure optimization strategy using in-die elastic recovery was developed to effectively address tablet lamination caused by air entrapment. This strategy involves exacerbating the air entrapment issue using high tableting speeds and main compaction pressures and collecting in-die…
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