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JRS Pharma
Characterization and evaluation of varieties of microcrystalline cellulose in formulations…
Abstract
The research study provides an insight into different manufacturers' microcrystalline celluloses (MCC) thorough characterization, comprising determination of morphology, PSD, percentage crystallinity, surface area, true density, crushing strength, and compaction behavior.
Highlights…
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Impact of antioxidant addition on drug dissolution: Implications for NDSRI mitigation biowaivers
Abstract
Nitrosamine impurities have garnered recent attention due to their presence in pharmaceuticals and their mutagenic risks. Recent studies have emphasized controlling impurities and suggest ways to mitigate the further formation of nitrosamines by the addition of antioxidants to tablets and…
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Development and Evaluation of Sublingual Tablet of Lercanidipine by Solid Dispersion Method
Abstract
The purpose of this study was to develop and evaluate a sublingual tablet of lercanidipine hydrochloride for the direct compression method of treating hypertension by using a solid dispersion technique. The dihydropyridine calcium-channel blocker lercanidipine Hydrochloride is used to…
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Application of Lactose Co-Processed Excipients as an Alternative for Bridging Pharmaceutical Unit…
Abstract
Improving the manufacturability of drug formulations via direct compression has been of great interest for the pharmaceutical industry. Selecting excipients plays a vital role in obtaining a high-quality product without the wet granulation processing step. In particular, for diluents which…
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Predicting the tabletability of binary powder mixtures from that of individual components
Abstract
Predicting the tabletability, i.e., the relationship between tensile strength and compaction pressure, of powder mixtures based on that of pure materials would streamline tablet formulation development, saving both time and materials. This would be a significant step toward achieving…
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3D-Printed cannabidiol stent for local treatment of urinary tract infections
Abstract
Urinary tract infections (UTIs) are highly prevalent among women and those assigned female at birth, and frequently necessitate the administration of systemic antibiotics, which contributes to the antibiotic resistance crisis due to overuse and suboptimal patient adherence. This study…
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Combining high throughput ASD screening with the rDCS to streamline development of poorly soluble…
Abstract
Poor aqueous solubility and slow dissolution rate of active pharmaceutical ingredients (APIs) are often encountered challenges during oral drug development, leading to variable and insufficient bioavailability. To overcome these challenges, a so-called “enabling” formulation strategy is…
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Development of Gastro-Retentive Combination Formulation of Montelukast Sodium and Bepotastine…
Abstract
Aim: The study aimed to develop a once-daily sustained-release gastroretentive combination formulation of bepotastine besilate and montelukast sodium using multilayer tablet technology and gastro-retentive systems for the treatment of allergic rhinitis and asthma.
Background:…
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Ethyl-Cellulose Nanosponges for Topical Delivery of Simvastatin with Preferential Skin Retention for…
Abstract
Novel topical nanosponges were implemented to improve the skin availability of simvastatin (SV) for treating full-thickness wounds while controlling the scarring process. SV exhibits great potential in treating various skin diseases owing to its antibacterial, antioxidant,…
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Effervescent Tablet Preparation by Twin-Screw Melt Granulation with Sorbitol as a Melt Binder
Abstract
Methods: Effervescent granules containing citric acid and sodium bicarbonate were successfully prepared for the first time via TS-MG using a polyol (sorbitol) as a melt binder.
Results: Processing parameters, specifically granulation temperature and screw speed, were systematically…
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