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JRS Pharma
Evidence of Reliable Gastro-Resistance of Novel Enteric Ready-to-Fill Capsules Simplifying…
Developing delayed-release formulations for acid-sensitive actives can be a costly and time-consuming process. However, ready-to-fill functional capsules, such as EUDRACAP® can significantly mitigate these challenges. The in vitro performance of EUDRACAP® enteric was evaluated in two typical…
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VITAMIN E – Direct Compression with PROSOLV 730
Aim of the study
Solid dose formulations of Vitamin E, an oily active ingredient, are typically produced as soft-gel capsules in the pharmaceutical and nutraceutical industry. The manufacturing process of these soft-gel capsules is labor-intensive and costly. The goal of this study was to create…
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Tableting properties of freeze-dried trehalose: physico-chemical and mechanical investigation
Abstract
Freeze-drying of biopharmaceutical products is the method of choice in order to improve their stability and storage conditions. Such Freeze-dried products are usually intended for parenteral route administration. However, many biopharmaceutical materials administered by parenteral route…
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Optimisation of the Manufacturing Process of Organic-Solvent-Free Omeprazole Enteric Pellets for the…
Abstract
Liquid formulations are mostly used in the paediatric population. However, with certain active pharmaceutical ingredients (APIs), it is very difficult to guarantee quality and stability; this is the case, for example, with omeprazole. Omeprazole is used as a model drug due to the lack of a…
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Determination of Gastric Water Emptying in Fasted and Fed State Conditions Using a…
Abstract
Because of the importance of gastric emptying for pharmacokinetics, numerous methods have been developed for its determination. One of the methods is the salivary tracer technique, which utilizes an ice capsule containing caffeine as a salivary tracer. Despite the ice capsule’s advantage…
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Application on the Direct Encapsulation Method in the Technology of Medicine with Dry Rauwolphia…
Abstract
The aim: Development of the composition and technology of a medicinal drug in the form of capsules with a dry
extract of Rauwolfia for the treatment of hypertension.
Materials and methods: Experimental samples of masses for encapsulation contained 2.0 mg of dry Rauwolfia
extract and…
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In Vivo Evaluation of a Gastro-Resistant Enprotect® Capsule under Postprandial Conditions
Ready-to-fill enteric hard capsule shells are an evolving field of oral drug and nutraceutical products. Lonza Capsugel® Enprotect® capsules were recently proven to provide reliable release in the small intestine after fasted intake, but robustness against postprandial intake needed to be proven. In…
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Application of Response Surface Methodology to Improve the Tableting Properties of Poorly…
Designing a robust direct compression (DC) formulation for an active pharmaceutical ingredient (API) with poor flow and compaction properties at a high API load is challenging. This study tackled two challenges: the unfavorable flow characteristics and tableting problems associated with a…
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The Impact of Polymer Mixture Composition on the Properties of Electrospun Membranes for Drug…
Orally dispersible films (ODFs) prepared by an electrospinning are a novel type of pharmaceutical formulation. This dosage form has the potential to be beneficial for small children and the elderly, who can have problems with administration of classical tablets due to the increased risk of choking…
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Comparison of Mini-Tablets and Pellets as Multiparticulate Drug Delivery Systems for Controlled Drug…
Mini-tablets made into hard capsules or administered using special dosing units, as well as pellets in hard capsules or compressed into tablets, offer the advantages of multiparticulate drug delivery systems and are suitable for controlled drug release using polymer coatings. Four different kinds of…
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