Lipoid

Lipoid is dedicated to continuously optimizing its production processes and product portfolio. For their product LIPOID PE 18:1/18:1 (DOPE), they are now launching a new product quality. The new product quality allows rapid and complete dissolution in ethanol and facilitates the processability for…
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Abstract Imiquimod (IMQ) is an immunostimulating agent used in the treatment of basal cell carcinoma and actinic keratosis. Due to its low solubility and poor skin bioavailability, the dermal formulation of IMQ remains challenging. In analogy to tyre compounds used in Formula 1 racing, we compare…
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A chitosan-coated luteolin-loaded phytocubosomal system was prepared to improve the pharmacodynamic performance of luteolin in the treatment of glaucoma and ocular inflammation after topical ocular administration. Luteolin, a potent anti-oxidant herbal drug with poor aqueous solubility, was…
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Phospholipids are amphiphilic, endogenous molecules with excellent biocompatibility and tolerability. Therefore, they are an ideal choice for various “over-the-counter” (OTC) products, including formulations for sensitive tissue such as the ocular surface. Phospholipids can serve as active…
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Photodynamic therapy (PDT) recently has been shown as a promising option in the treatment of premalignant lesions of the soft oral tissues. Effective delivery of photosensitizer is challenging due to poor drug adherence to the oromucosal epithelium. In the present work, emulgels composed of natural…
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Solubility is a critical parameter controlling drug absorption after oral administration. For poorly soluble drugs, solubility is influenced by the complex composition of intestinal media and the influence of dosage form excipients, which can cause bioavailability and bioequivalence issues. This…
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Lung carcinoma characterized by high mortality rate and poor prognosis; the efficacy of drug delivery should improve drug exposure at the targeted site. This study aims at evaluating lactoferrin role as targeting ligand besides the administration route impact on tissue deposition and organ…
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Processed excipients (PEs) function in creating various dosage forms and need no introduction. For instance, recent studies have shown that PEs oleic acid, which is used with the breast cancer medicine Herceptin, functions both as a liquid delivery system for drugs and has the ability to suppress…
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Ophthalmic delivery of luteolin (LU) was studied after formulating a carrageenan-based novel ion-sensitive in situ gel (ISG) incorporating oleophytocubosomes for prolonged ocular residence time and improved ocular bioavailability of the poorly absorbed herbal drug luteolin. The prepared…
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Liver fibrosis is a condition characterized by the accumulation of extracellular matrix (ECM) arising from the myofibroblastic transdifferentiation of hepatic stellate cells (HSCs) occurring as the natural response to liver damage. To date, no pharmacological treatments have been specifically…
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