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Meggle
Effect of Powdered Cellulose Nanofiber with Different Particle Sizes on the Physical Properties of…
Abstract
Direct compression is a tableting technique that involves a few steps in non-demanding manufacturing conditions. High strength and rapid disintegration of tablet formulations were previously achieved through the addition of cellulose nanofibers (CNFs), which have recently attracted…
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The importance of Excipient selection for modified release formulations – prevent the risk for…
Introduction
The oral route is the main acceptable route, which offers more patient compliance and cost-effective manufacturing processes. Pharmaceutical dosage forms may be developed in which drug release characteristics with respect to time and/or location have in some way been modified compared…
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InhaLac® 145 – The interview
MEGGLE announced the release of its new lactose product InhaLac® 145 yesterday.
Pharma Excipients had the opportunity to speak with Dr. Constanze Müller, Manager Business Development Inhalation and one of the persons behind the development of InhaLac® 145 to get more background information on the…
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InhaLac® 145 – MEGGLE launches new milled lactose grade
Wasserburg, Germany, December, 2023:
Pharmaceutical lactose specialist MEGGLE will use the Drug Delivery to the Lungs (DDL) Conference in Edinburgh, Scotland, to launch InhaLac® 145 as the latest addition to its wide range of lactose-based dry powder inhalation (DPI) excipients.
MEGGLE’s…
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Tableting properties of freeze-dried trehalose: physico-chemical and mechanical investigation
Abstract
Freeze-drying of biopharmaceutical products is the method of choice in order to improve their stability and storage conditions. Such Freeze-dried products are usually intended for parenteral route administration. However, many biopharmaceutical materials administered by parenteral route…
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Supercritical antisolvent-fluidized bed for the preparation of dry powder inhaler for pulmonary…
The supercritical antisolvent-fluidized bed coating process (SAS-FB) shows great potential as a technique to manufacture dry powder inhaler (DPI) that incorporate nanodrugs onto micronized matrix particles, capitalizing on the merits of both nanoparticle and pulmonary delivery. In this study,…
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Optimisation of the Manufacturing Process of Organic-Solvent-Free Omeprazole Enteric Pellets for the…
Abstract
Liquid formulations are mostly used in the paediatric population. However, with certain active pharmaceutical ingredients (APIs), it is very difficult to guarantee quality and stability; this is the case, for example, with omeprazole. Omeprazole is used as a model drug due to the lack of a…
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Suitability of Wurster-Fluid Bed technique for functional Eudragit L-100 coating on tablet cores
Introduction
Film coating of solid dosage forms in pharmaceutical manufacturing is carried out using range of equipment, process parameters and coating formulations to achieve the quality target profile of the dosage form. Besides for aesthetic reasons, film coatings are mostly applied to modify…
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Comparison of Mini-Tablets and Pellets as Multiparticulate Drug Delivery Systems for Controlled Drug…
Mini-tablets made into hard capsules or administered using special dosing units, as well as pellets in hard capsules or compressed into tablets, offer the advantages of multiparticulate drug delivery systems and are suitable for controlled drug release using polymer coatings. Four different kinds of…
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The influence of directly compressible fillers/diluents on selected compact properties and drug…
Introduction
Direct compression represents a favorable tablet manufacturing method. However, obtaining satisfactory mechanical properties of the compacts and drug dissolution remains a challenge in formulation development, particularly in the case of challenging model drugs. Rivaroxaban is…
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