Shin-Etsu

Abstract Currently, most amorphous solid dispersion (ASD) formulations contain a single polymer to stabilize an amorphous drug. However, a single polymer has a limited ability to form strong drug-polymer interactions, resulting in poor drug loading (<30 % w/w) and a high pill burden. This…
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Abstract Bethanechol chloride (BTC), a quaternary ammonium compound used in bladder dysfunction treatment, requires challenges in developing optimal oral dosage forms due to its high water-solubility, short half-life, rapid elimination and four times a day administration. The aim of this study…
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Abstract S-Adenosylmethionine (SAMe) is a crucial endogenous molecule in vital biochemical processes such as DNA, RNA, and protein methylation. It has been found beneficial in the treatment of liver disease, osteoarthritis, and particularly depression. However, SAMe's therapeutic potential is…
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Abstract Previous research has shown that controlled release (CR) formulations with hydrox- ypropyl methylcellulose (HPMC) as hydrophilic matrix former produced via twin-screw wet granulation (TSWG) yield granules with an inhomogeneous active pharmaceutical ingredient (API) distribution (Denduyver…
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Solid pharmaceutical dosage forms, such as tablets and capsules, are the most used drug delivery systems, favored for their ease of production and patient preference. These forms combine active pharmaceutical ingredients (APIs) with excipients that are carefully selected and processed to ensure…
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Abstract Amorphous solid dispersions (ASDs) have been extensively utilized to improve the bioavailability of drugs that have low aqueous solubility. The influence of different excipients on the conversion of amorphous drugs into their crystalline forms in ASDs has been extensively researched.…
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Abstract Background/Objectives: The aim of the present study was to develop lactose-free formulations of rivaroxaban, a novel oral anticoagulant used for the treatment and prevention of blood clotting. As a BCS Class II drug, rivaroxaban is characterized by poor solubility in aqueous media, posing…
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Abstract Invasive pulmonary aspergillosis poses a significant threat to immunocompromised patients, characterized by high mortality rates. Posaconazole (PSZ), a second-generation triazole antifungal, exhibits broad-spectrum activity but suffers from limited pulmonary concentrations and notable…
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Abstract Orodispersible films (ODFs) have served as an emerging platform for the delivery of drugs in a convenient way. The production of ODFs with incorporated pellets may still be a challenging process due to problems to obtain proper homogeneity and deteriorating mechanical properties of the…
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Abstract Fluidized bed granulation is a single unit operation that integrates several process transformations including powder transfer and fluidization, atomization of binder solution and wetting of the fluidized powder, growth and consolidation of granules, drying, and discharge of the granular…
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