Pharma Excipients
Suspension Agent
Viscosity of API/fatty acid suspensions: Pitfalls during analysis
This article describes how to obtain reliable data during rheological analysis of active pharmaceutical ingredient/fatty acid suspensions. These materials are specifically used for prilling, an innovative pharmaceutical technique for the production of a multiparticulate dosage form. Nevertheless,…
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Towards an Improved Understanding of Drug Excipient Interactions to Enable Rapid Optimization of…
Suspensions of drug nanoparticles known as nanosuspensions have emerged as a successful enabling formulation approach for poorly soluble drug candidates. These nanoparticles typically require stabilization with specific polymer or surfactant excipients to prevent aggregation from occurring.
This…
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Olopatadine hydrochloride loaded Kollidon® SR nanoparticles for ocular delivery: Nanosuspension…
Introduction
Allergic eye diseases includes a spectrum of diseases, with each state being characterized by a complicated immunopathology. In the present study, polymeric Kollidon® SR nanoparticles loaded with olopatadine hydrochloride (OLO) were formulated as a suspension for ocular drug…
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Development of a safe and versatile suspension vehicle for pediatric use
This project aimed to develop a suspension vehicle specifically designed for pediatric use. Excipients were selected according to their safety and recorded use in pediatrics. Two suspension vehicles were formulated at neutral and acidic pH. A few compositions were defined, and their physicochemical…
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Evaluation of improved oral bioavailability of ritonavir nanosuspension
The main objective of this study was to evaluate the pharmacokinetics of ritonavir (RTV) nanosuspension in rats in both fed and fasted state in comparison with coarse powder, physical mixture and commercial product (Norvir®). The point to point relation model was generated between the results of in…
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Current Developments in Excipient Science – Implication of Quantitative Selection of Each…
Implication of Quantitative Selection of Each Excipient in Product Development
Excipients’ role in designing different dosage forms does not require any introduction. These are the additives that are added to the formulation along with pharmacologically active substance. The main purpose of adding…
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Development and stability of an oral suspension of procarbazine in pediatrics
Many drugs used in pediatric oncology are not labeled and adapted for pediatric use, such as caps of procarbazine to treat gliomas in children under 6 years old. Indeed, pediatric patients present difficulties to swallow these caps and it can lead to major observance problems. To provide a solution…
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The central role of excipients in drug formulation
Active substances are rarely administered alone. For example, levothyroxine, a synthetic form of the thyroid hormone, indicated in the treatment of hypothyroidism, is administered at a very low dosage, ranging from 15 μg to 200 μg. These very small amounts of powder mean that it is not possible…
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