Pharma Excipients
Sustained Release Agent
Extended release of flurbiprofen from tromethamine-buffered HPMC hydrophilic matrix tablets
The continued popularity into the 21st century of extended release matrices based on hydroxypropyl methylcellulose (HPMC) can be attributed to (i) the effectiveness of hydrophilic matrix technology, (ii) the high acceptability of the polymer, (iii) the ease of dosage form manufacture and (iv) a…
Read More...
Read More...
Sketching feasibility of additively manufactured different size gradient conventional hollow…
Additive manufacturing (AM) is widely used to fabricate 3D printed objects from Computer-aided Design (CAD) prepared using the SolidWorks CAD modelling software. Different printing techniques are used to fabricate desired 3D objects; among all these techniques, it is widely accepted that SLS is one…
Read More...
Read More...
A dual catalytic functionalized hollow mesoporous silica-based nanocarrier coated with…
Abstract
In this study, we introduced a multifunctional hollow mesoporous silica-based nanocarrier (HMSN) for the targeted delivery of irinotecan (IRT) to colorectal cancer cells. Due to their large reservoirs, hollow mesoporous silica nanoparticles are suitable platforms for loading significant…
Read More...
Read More...
Sustained release polymer and surfactant based solid dispersion of andrographolide exhibited…
Andrographolide (AD) is a potent natural product with a wide range of pharmacological activities. However, it has low oral bioavailability due to poor solubility and dissolution rate. Solid dispersion (SD) is a promising technique to improve the solubility and dissolution rate of such molecules. In…
Read More...
Read More...
TPGS/soluplus® blended micelles: an effective strategy for improving loading capacity of ferroptosis…
Erastin is the most classical small molecular ferroptosis inducer but its clinical application is hindered due to its poor solubility. Nanotechnology has been used to improve ferroptosis inducer erastin’s solubility. The recently reported erastin-incorporated nanosystems (e.g., nanoparticulate…
Read More...
Read More...
Effect of Croscarmellose Sodium in Sustained Release Layer of Valsartan in Bilayer Tablet with…
The aim of the study was to design and evaluate bilayer tablets of clopidogrel as immediate release and quick relief and valsartan for sustained release and check the effect of croscarmellose sodium (2%) in Carbopol for sustained release action. Bilayer tablets was prepared using direct compression…
Read More...
Read More...
Development, Physicochemical Characteristics and Pharmacokinetics of a New Sustained-Release Bilayer…
Abstract
Background and Objective
There are some potential concerns about the currently marketed solid oral dosage forms of tramadol, including decreased adherence to immediate-release (IR) formulations due to the high number of doses taken each day and the slow rise in the blood tramadol…
Read More...
Read More...
Characterizing a design space for a twin-screw wet granulation process: A case study of…
Abstract
Twin-screw wet granulation is an emerging continuous manufacturing technology for solid oral dosage forms. This technology has been successfully employed for the commercial manufacture of immediate-released tablets. However, the higher polymer content in extended-release (ER) formulations…
Read More...
Read More...
Pharmaceutical Formulations for Older Patients – Part 2
See the new book, edited by Mine Orlu, Fang Liu
Provides a better understanding on the EMA reflection paper on pharmaceutical development for older patients
Details reasons for applying advanced pharmaceutical technologies for the benefit of the ageing population
Discusses Advanced…
Read More...
Read More...
Viatel™ Bioresorbable Polymers – by Ashland
Ashland is a premier global specialty chemicals company serving customers in a wide range of consumer and industrial markets. With the Viatel™ platform, Ashland offers five families of bioresorbable polymers for parenteral controlled release drug delivery systems and medical devices.
viatel™…
Read More...
Read More...