Pharmaceutical Starter Cores For Scalable Solutions in Pharma

CELLETS® Pharmaceutical Starter Cores for Pellets & Functional Coatings

CELLETS® are high-purity pharmaceutical starter cores. They combine spherical geometry with narrow particle size distribution and defined density. They provide reproducible carriers for functional coatings and enable controlled layer formation in fluid bed and drum coating processes. Thanks to their uniform geometry, CELLETS® ensure stable fluidization, consistent rolling, and homogeneous wetting during coating. This guarantees uniform layer thicknesses and precise control of active ingredient release.

In controlled-release applications—such as sustained-release, delayed-release, or gastro-resistant systems—CELLETS® support reproducible release profiles. They minimize variability in active ingredient application and polymer layer thickness, creating robust, scalable formulations. CELLETS® enable efficient transfer from formulation development to production scale, improving process reliability and batch-to-batch consistency.

Standardized Starter Cores for GMP-Compliant Processes

CELLETS® are manufactured under controlled conditions with reproducible physical properties. Their narrow particle size, defined density, and high sphericity support consistent process control. This facilitates equipment and process qualification. Regulatory documentation (e.g., DMF information) and GMP compatibility allow CELLETS® to be used across the entire product lifecycle. Using standardized starter cores reduces regulatory risks and supports process validation and batch consistency.

Seamless Transfer from Development to Production

CELLETS® enable a smooth scale-up from lab to pilot and commercial production without altering material properties. This simplifies understanding and control of critical process parameters (CPPs). Formulations developed on CELLETS® can scale reproducibly, shortening development timelines and minimizing process adjustments.

Controlled Release & Enteric Coating Precision

CELLETS® provide a neutral, robust core for controlled or delayed drug release. Their uniform surface allows homogeneous application of functional polymer layers, such as sustained-release or enteric coatings. They reduce variability in layer thickness and drug distribution, ensuring reproducible release profiles. CELLETS® support the development of stable controlled-release and enteric coating systems in both R&D and commercial production.

Read the original article here

Source: ingredientpharm, website Pharmaceutical Starter Cores For Scalable Solutions in Pharma – Cellets

Enjoy the interview from ingredientpharm at the CPHI:

Interested in a sample from ingredientpharm?