excipients

Abstract The recent advancement of 3D-printed drugs is an emerging technology that has the potential for effective and safe oral delivery of personalized treatment regimens to patients, replacing the current “one size fits all” philosophy. The objective of this literature review is to highlight the…
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Sesame oil is well known in kitchens for its rich flavor and health benefits—but pharmaceutical use requires far more than taste. Refined Sesame Oil IV-1 is a highly specialized excipient designed for strict pharmaceutical standards where purity, consistency, and stability are non-negotiable. This…
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Abstract Topical drug delivery systems offer a targeted and patient-compliant approach for managing psoriasis, enabling noninvasive, localized, and sustained therapy, with reduced systemic side effects and improved therapeutic outcomes. In this study, we prepared phospholipid complex (PLC) based…
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Abstract An industrial-scale pharmaceutical powder blending process was studied via discrete element method (DEM) simulations. A DEM model of two active pharmaceutical ingredient (API) components and a combined excipient component was calibrated by matching the simulated response in a dynamic angle…
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Abstract Aim In this study, we developed a dual pH and time-dependent formulation for targeted colonic release, aiming at minimizing adverse effect and enhancing anticancer efficacy of colchicine in the treatment of colorectal cancer. Article highlights The findings of this study…
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Abstract The development of a robust oral solid dosage form requires knowledge of all the sources of variation that could impact the dosage form’s performance and stability, in line with Quality-by-Design (QbD). This requires a deep understanding of the relationships between raw material…
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Abstract Olanzapine (OLZ) is classified as a typical antipsychotic drug utilized for treatment of schizophrenia, it possesses poor oral bioavailability (60%) due to low solubility and first-pass hepatic metabolism. Hence, the aim of present work is to fabricate and evaluate an olanzapine…
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Abstract Metformin is a relatively old drug mainly used to treat type 2 and gestational diabetes, which needs to be administered two or three times a day in high doses. It has a high aqueous solubility and is poorly absorbed following oral intake. Aiming to achieve a gastroretentive formulation for…
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Abstract Microcrystalline cellulose (MCC) is extensively used in pharmaceutical formulations due to its exceptional functionality as a diluent, dry binder, disintegrant, and absorbent. Despite being marketed in numerous grades that vary in particle size, source, extraction techniques, and…
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Abstract Vaginal drug delivery has gained significant interest due to its numerous advantages, such as good blood flow, bypassing the first-pass effect, low systemic side effects, and potential for sustained release of pharmaceuticals. Initially targeting contraception and local effects from…
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