excipients

Abstract Transforming poorly soluble active pharmaceutical ingredients (APIs) into a nanoparticulate form is a proven way of improving their dissolution characteristics. The preparation of API nanosuspensions is commonly achieved by wet-stirred media milling. The challenge lies in converting the…
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Abstract Diffuse intrinsic pontine glioma (DIPG) poses a significant treatment challenge in pediatric patients due to its aggressive nature and difficulty in crossing the blood–brain barrier with effective therapies. ONC201 (dordaviprone) shows promises in inducing apoptosis in cancer cells but…
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Abstract The growing issues with prescription drug misuse have required the development of advanced techniques like abuse-deterrent formulations (ADFs). In this abstract we have provided a comprehensive overview of these type of novel formulations and their potential impact on mitigating…
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The patent application titled “Modified Release Gamma-Hydroxybutyrate (GHB) Formulations Having Improved Pharmacokinetics” (US20240148685) focuses on improving the delivery of GHB, a substance used for treating sleep disorders like narcolepsy, through modified-release formulations. The goal is to…
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Solid pharmaceutical dosage forms, such as tablets and capsules, are the most used drug delivery systems, favored for their ease of production and patient preference. These forms combine active pharmaceutical ingredients (APIs) with excipients that are carefully selected and processed to ensure…
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Abstract Vaginal yeast infections, such as vulvovaginal candidiasis (VVC), affect nearly three out of four women worldwide. Re-occurrence is frequent and requires repeated treatments with oral, antifungal medications at high doses. Prolonged treatments contribute to development of resistant…
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Abstract Amphotericin-b (AmB) is a broad-spectrum polyene macrolide antifungal and anti-Leishmaniosis. We addressed HSPiP and QbD (quality by design) oriented HPLC (high-performance liquid chromatography) method development and validation, followed by identifying critical attributes on retention…
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Abstract Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have emerged as promising systems for delivering active ingredients. They are derived from physiological, biodegradable, and biocompatible lipids, offering benefits such as sustained release promotion and increased…
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Abstract Powders used in pharmaceuticals require good flowability. The angle of repose and compressibility index are often used to measure the flowability of pharmaceutical powders. However, confirming the relationship between external forces and flowability for smooth powder handling is necessary.…
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In the ever-evolving pharmaceutical landscape, ensuring the stability and efficacy of moisture-sensitive and hydrophilic formulations is crucial. That's where PureCoat® MPS-D comes in - a ready-to-prepare film coating system designed specifically for solid oral dosage forms from Sigachi. With its…
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