Browsing Category
Taste Masking
Taste Masked Artesunate/Amodiaquine Micropellets in the Fight Against Malaria
This article shows the content of a poster which was presented at the 𝗘𝗨𝗣𝗳𝗜 𝗰𝗼𝗻𝗳𝗲𝗿𝗲𝗻𝗰𝗲 𝗶𝗻 𝗚𝗹𝗮𝘀𝗴𝗼𝘄 2023
Malaria & Treatment Challenges
Children aged under 5 years are the worst affected by malaria, causing about 10 % of all children’s deaths in regions where malaria is endemic. Fixed dose…
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The effect of excipients on oral lyophilizates quality attributes
Pharmaceutical industry is constantly focused on researching patient-centered dosage forms that can maximize the therapeutic potential of an active pharmaceutical ingredient, as for example orodispersible form. The main advantage of orodispersible dosage forms is that they are suitable for patients…
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A Guide to Best Practice in Sensory Analysis of Pharmaceutical Formulations
It is well established that treatment regime compliance is linked to the acceptability of a pharmaceutical formulation, and hence also to therapeutic outcomes. To that end, acceptability must be assessed during the development of all pharmaceutical products and especially for those intended for…
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Paediatric Medicinal Formulation Development: Utilising Human Taste Panels and Incorporating Their…
This review paper explores the role of human taste panels and artificial neural networks (ANNs) in taste-masking paediatric drug formulations. Given the ethical, practical, and regulatory challenges of employing children, young adults (18–40) can serve as suitable substitutes due to the similarity…
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MicroCoat™: A Breakthrough in Oral Multiparticulate Formulation Development
Oral multiparticulate systems are often the ‘go to’ solution for flexible dosing, especially in cases where a degree of functionality, such as taste masking or modified release, is required from the formulation. One of the preferred methods of adding functionality to multiparticulates is by fluid…
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Investigation of the Kollicoat Smartseal formulation concepts on the taste masking functionality
Did you know that based on the virtual tool BitterPredict, about 40% of random molecules, 66% of clinical and experimental drugs, and almost 77% of natural products are bitter1?
This leads us to concern about the final formulation's palatability and look for alternatives to overcome the…
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Formulation development with Kollicoat Smartseal: Impact of plasticizers
How can plasticizers impact the functionality of film-coating latex-based dispersion?
When formulating a film coating, plasticizers are often required to increase polymer chain mobility, improve mechanical properties, such as elasticity and cracking resistance, and reduce the minimum film…
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The impact of common pharmaceutical excipients on the gut microbiota
ABSTRACT
Introduction
Increasing attention is being afforded to understanding the bidirectional relationships that exist between oral medications and the gut microbiota, in an attempt to optimize pharmacokinetic performance and mitigate unwanted side effects. While a wealth of research has…
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2-Hydroxypropyl-β-Cyclodextrin Treatment Induces Modest Immune Activation in Healthy Rhesus Macaques
Experimental simian immunodeficiency virus (SIV) infection of Asian macaques is an excellent model for HIV disease progression and therapeutic development. Recent coformulations of nucleoside analogs and an integrase inhibitor have been used for parenteral antiretroviral (ARV) administration in…
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Kollicoat® Smartseal combines an effective taste-masking functionality with efficient processing
Kollicoat® Smartseal 30 D and Kollicoat® Smartseal 100 P can help formulators tackle challenges when handling bitter active ingredients. It offers superior protection from unpleasant drug taste for minitablets, pellets, particles, and granules used in orally disintegrating dosage forms, improving…
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