Ultrasound assisted preparation of novel ibuprofen loaded excipient with improved compression and dissolution properties
Context: Most of the active pharmaceutical ingredients (APIs) suffer from a drawback of poor aqeous solubility. In addition to the same, some APIs show poor tabletting behavior creating problems in formulation development. Crystal engineering can be an efficient tool in rectification of such problems associated with the APIs. Thus present work deals with crystallization of ibuprofen (a model drug) onto the surface of dicalcium phosphate (DCP) particles using different techniques.
Objective: The objective of the present work was to prepare ibuprofen loaded DCP particles and further to analyze them for compressibility and dissolution behavior.