Continuous manufacturing

Abstract Modern pharmaceutical manufacturing based on Quality by Design and digitalisation is revolutionising the pharmaceutical industry. Continuous processes are promoted as they increase efficiency and improve quality control. Compared to batch blending, continuous blending is easier to scale…
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Handbook of Post-Processing in Additive Manufacturing See the new book, edited by Gurminder Singh, Ranvijay Kumar, Kamalpreet Sandhu, Eujin Pei, Sunpreet Singh. Description: Handbook of Post-Processing in Additive Manufacturing is a key resource on postprocessing treatments available for…
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Handbook of Post-Processing in Additive Manufacturing See the new book, edited by Gurminder Singh, Ranvijay Kumar, Kamalpreet Sandhu, Eujin Pei, Sunpreet Singh. Description: Handbook of Post-Processing in Additive Manufacturing is a key resource on postprocessing treatments available for…
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As is the case with batch-based tableting processes, continuous tablet manufacturing can be conducted by direct compression or with a granulation step such as dry or wet granulation included in the production procedure. In this work, continuous manufacturing tests were performed with a commercial…
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Highlights • Multifunction machine for inspection, counting and bottle filling • Exceptional 100% visual inspection of tablets, capsules & softgels • Product sorting before final counting and filling • Easy adjustment for bottles of different size and type • Filling bottles with count from…
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Introduction Pharmaceutical companies are increasingly investing in automated visual inspection and sorting machines in order to replace subjective and costly manual sorting. These machines need to efficiently replace human hands by automatic mechanical manipulators, human eyes by digital video…
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Conventional cyclodextrin complexation enhances the solubility of poorly soluble drugs but is solvent-intensive and environmentally unfavorable. This study evaluated solvent-free hot-melt extrusion (HME) for forming cyclodextrin inclusion complexes to improve the solubility and dissolution of…
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ABSTRACT Oral administration of medicine is one of the most common delivery routes still in use today. Various dosage forms are administered via the oral route including tablets, capsules, syrups, solutions and emulsions. Tablets constitute a large part of orally available dosage forms due to ease…
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Abstract Pharmaceutical continuous manufacturing provides the appropriate tools (e.g. the understanding of process dynamics and appropriate and adaptable control strategy) in order to deal with Quality-by-Design expectations and even to the future smart manufacturing described by…
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Summary Continuous production has now been adopted even in the pharmaceutical industry and is indispensable in current product developments. This study focuses on the process of continuous direct compression, with the aim of guaranteeing constant product quality over the whole production run. A…
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