Continuous manufacturing

Abstract The dynamics of cohesive particles and their tendency to adhere to surfaces present significant challenges in various industrial processes. A profound understanding of adhesive and cohesive forces is crucial for the optimized design of continuous manufacturing systems, aiming to…
Read More...

Introduction Many respiratory pathogens enter the body through the respiratory tract, the lungs and the mucosal immune system are promising targets for therapeutic interventions. Liquid vaccines face the risk of chemical degradation and physical instability -> Solid formulations can…
Read More...

Twin-screw wet granulation (TSG) is a continuous manufacturing technique either for granules as final dosage form or as an intermediate before tableting or capsule filling. A comprehensive process understanding is required to implement TSG, considering various parameters influencing granule and…
Read More...

ABSTRACT Introduction: The pharmaceutical industry is gradually changing batch-wise manufacturing processes to continuous manufacturing processes, due to the advantages it has to offer. The final product quality and process efficiency of continuous manufacturing processes is among others impacted…
Read More...

Vesicants are chemical warfare agents (CWAs) capable of causing severe skin damage and systemic toxicity. Melatonin, known for its anti-inflammatory and antioxidant properties, can mitigate the effects of these agents. Self-nano-emulsifying drug delivery systems (SNEDDS) containing a high melatonin…
Read More...

Purpose Continuous manufacturing (CM) gains more and more interest in the pharmaceutical industry, which is guided by the FDA in Pharma 4.0. With CM gaining ever so importance, understanding of physical properties of powders to predict behavior in different process units is crucial. Raw…
Read More...

Over the past decade, continuous manufacturing has garnered significant attention in the pharmaceutical industry. Still, numerous continuous unit operations need developments, such as powder blending and feeding at low and high throughputs. Especially the continuous and consistent feeding of solid…
Read More...

Learn the step-by-step process of gelatin production, from raw material preparation to the final product. This guide covers both the hot melt and cold melt methods, equipment needed, and common issues encountered in the manufacturing process. Production of Gelatin The production of gelatin for…
Read More...

Real-time monitoring of critical quality attributes, such as residual water in granules after drying which can be determined through loss-on-drying (LOD), during wet granulation and drying is essential in continuous manufacturing. Near-infrared (NIR) spectroscopy has been widely used as process…
Read More...

Producing soft gelatin capsules (softgels) involves meticulous attention to detail and a deep understanding of the materials and processes. In this article, we will delve into the critical aspects of fill material production, exploring techniques to ensure uniformity, the importance of equipment,…
Read More...