Continuous manufacturing

Abstract Oral drug delivery remains the preferred method of drug administration but due to poor solubility many active pharmaceutical ingredients (APIs) are ill suited to this. A number of methods to improve solubility of poorly soluble Biopharmaceutical Classification System (BCS) Class II drugs…
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Abstract In recent years, continuous manufacturing (CM) has become increasingly popular in the pharmaceutical industry for the production of oral solid dosage (OSD) forms. Most of the newly developed active pharmaceutical ingredients (APIs) nowadays are extremely cohesive and sticky with a mean…
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Abstract Process Analytical Technology (PAT) plays a crucial role in the design of today’s manufacturing lines as continuous manufacturing becomes more important. Until now PAT tools to measure the ribbon solid fraction (SFribbon) in-line are not commonly used in roll compaction. The aim of this…
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Many challenges – one solution: Fumed silica as well as precipitated silica and silicates from Evonik are some of the most important and highly utilized pharmaceutical excipients. Whether you manufacture medicines for solid, semi-solid or liquid dosing, we support you at every stage of product…
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High-quality lubricants for solid oral dosage forms BASF's Lubricant Portfolio includes hydrophilic and hydrophobic GMP-grade excipients to ensure high performance and robust tableting operations. Choose from a range of tailored solutions for batch or continuous manufacturing. What is a…
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Softgel capsules are a cornerstone of modern pharmaceutical and nutraceutical industries, offering consumers a seamless, easy-to-swallow solution that enhances bioavailability and ensures precise dosing. This article will examine the intricate processes involved in softgel encapsulation,…
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Abstract Electrospinning (ES) is a promising continuous formulation strategy to produce amorphous solid dispersions (ASDs) and thereby improve the dissolution of poorly water-soluble drugs. However, processing the electrospun material into solid dosage forms (e.g. tablets) is challenging due to…
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Abstract In this work, real-time optimization (RTO) schemes are proposed and applied on a continuous pharmaceutical manufacturing process which consists of three units: synthesis unit, hot melt extrusion unit and direct compaction line. The developed RTO strategies calculate the operating…
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Abstract The pharmaceutical industry is continuously looking for strategies and solutions that can improve quality and efficiency of manufacturing processes. As a result, there has been a significant shift towards continuous manufacturing (CM). Traditionally, tablets have been produced by batch…
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Abstract Background/Objectives: Amorphization of an active pharmaceutical ingredient (API) can improve its dissolution and enhance bioavailability. Avoiding solvents for drug amorphization is beneficial due to environmental issues and potential solvent residues in the final product. Methods: Dry…
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