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Continuous manufacturing
Loss-on-Drying Prediction for a Vibrated Fluidised Bed Dryer by Means of Mass and Energy Balances
Abstract
Purpose
Continuous wet granulation and drying require an adequate process control strategy to ensure the product quality. The most important critical quality attributes of dried granules are the granule size distribution and moisture content. Process analytical technologies (PATs) are…
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Characterizing a design space for a twin-screw wet granulation process: A case study of…
Abstract
Twin-screw wet granulation is an emerging continuous manufacturing technology for solid oral dosage forms. This technology has been successfully employed for the commercial manufacture of immediate-released tablets. However, the higher polymer content in extended-release (ER) formulations…
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Lubricant Sensitivity of Direct Compression Grades of Lactose in Continuous and Batch Tableting…
Abstract
Modern pharmaceutical manufacturing based on Quality by Design and digitalisation is revolutionising the pharmaceutical industry. Continuous processes are promoted as they increase efficiency and improve quality control. Compared to batch blending, continuous blending is easier to scale…
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Handbook of Post-Processing in Additive Manufacturing – Part 2
Handbook of Post-Processing in Additive Manufacturing
See the new book, edited by Gurminder Singh, Ranvijay Kumar, Kamalpreet Sandhu, Eujin Pei, Sunpreet Singh.
Description: Handbook of Post-Processing in Additive Manufacturing is a key resource on postprocessing treatments available for…
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Handbook of Post-Processing in Additive Manufacturing – Part 1
Handbook of Post-Processing in Additive Manufacturing
See the new book, edited by Gurminder Singh, Ranvijay Kumar, Kamalpreet Sandhu, Eujin Pei, Sunpreet Singh.
Description: Handbook of Post-Processing in Additive Manufacturing is a key resource on postprocessing treatments available for…
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Challenges encountered in the transfer of atorvastatin tablet manufacturing – commercial…
As is the case with batch-based tableting processes, continuous tablet manufacturing can be conducted by direct compression or with a granulation step such as dry or wet granulation included in the production procedure. In this work, continuous manufacturing tests were performed with a commercial…
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SPINE FIBO – Automatic Visual Inspection, Counting and Bottle Filling of Tablets &…
Highlights
• Multifunction machine for inspection, counting and bottle filling
• Exceptional 100% visual inspection of tablets, capsules & softgels
• Product sorting before final counting and filling
• Easy adjustment for bottles of different size and type
• Filling bottles with count from…
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Investing in automated visual inspection and sorting machines: costs, risks and performance…
Introduction
Pharmaceutical companies are increasingly investing in automated visual inspection and sorting machines in order to replace subjective and costly manual sorting. These machines need to efficiently replace human hands by automatic mechanical manipulators, human eyes by digital video…
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Continuous Manufacturing of Solvent-Free Cyclodextrin Inclusion Complexes for Enhanced Drug…
Conventional cyclodextrin complexation enhances the solubility of poorly soluble drugs but is solvent-intensive and environmentally unfavorable. This study evaluated solvent-free hot-melt extrusion (HME) for forming cyclodextrin inclusion complexes to improve the solubility and dissolution of…
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Evaluation of tricalcium citrate as a direct compressible diluent using the SeDeM Expert Diagram…
ABSTRACT
Oral administration of medicine is one of the most common delivery routes still in use today. Various dosage forms are administered via the oral route including tablets, capsules, syrups, solutions and emulsions. Tablets constitute a large part of orally available dosage forms due to ease…
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