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Continuous manufacturing
Proof of a LOD prediction model with orthogonal PAT methods in continuous wet granulation and drying
Real-time monitoring of critical quality attributes, such as residual water in granules after drying which can be determined through loss-on-drying (LOD), during wet granulation and drying is essential in continuous manufacturing. Near-infrared (NIR) spectroscopy has been widely used as process…
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The Ultimate Guide to Soft Gelatin Capsule Manufacturing
Producing soft gelatin capsules (softgels) involves meticulous attention to detail and a deep understanding of the materials and processes. In this article, we will delve into the critical aspects of fill material production, exploring techniques to ensure uniformity, the importance of equipment,…
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Blend uniformity monitoring in a continuous manufacturing mixing process for a low-dosage…
Continuous manufacturing has the potential to offer several benefits for the production of oral solid dosage forms, including reduced costs, low-scale equipment, and the application of process analytical technology (PAT) for real-time process control. This study focuses on the implementation of a…
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Process analytical technology in Downstream-Processing of Drug Substances – A review
Abstract
Process Analytical Technology (PAT) has revolutionized pharmaceutical manufacturing by providing real-time monitoring and control capabilities throughout the production process. This review paper comprehensively examines the application of PAT methodologies specifically in the production…
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Learn and enhance your skills in formulation and tableting thanks to STYL’One Nano
In the rapidly evolving field of pharmaceutical sciences, innovative tools and technologies are essential to advancing research and development. One such innovative instrument is the STYL'One Nano, offered by MEDELPHARM. This compact yet powerful R&D compaction simulator has proven to be an…
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Evaluation of Polyvinyl Alcohol as Binder during Continuous Twin Screw Wet Granulation
Binder selection is a crucial step in continuous twin-screw wet granulation (TSWG), as the material experiences a much shorter residence time (2–40 s) in the granulator barrel compared to batch-wise granulation processes. Polyvinyl alcohol (PVA) 4-88 was identified as an effective binder during…
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Process intensification of pharmaceutical powder blending at commercial throughputs by utilizing…
Abstract
Process intensification involves the miniaturization of equipment while retaining process throughput and performance. The pharmaceutical industry can benefit from this approach especially during drug product development, where the availability of active pharmaceutical ingredients (API)…
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The effect of material properties and process parameters on die filling at varying throughputs: A…
Abstract
When tablets are manufactured on a rotary tablet press and the throughput is increased, it leads to changes in powder dynamics during die filling due to formulation characteristics and changing powder flow in the feed frame. This may result, a.o. in increased tablet weight variability,…
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Formulation Development and Evaluation of Cannabidiol Hot-Melt Extruded Solid Self-Emulsifying Drug…
Cannabidiol (CBD) is a highly lipophilic compound with poor oral bioavailability, due to poor aqueous solubility and extensive pre-systemic metabolism. The aim of this study was to explore the potential of employing Hot Melt Extrusion (HME) technology for the continuous production of Self…
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Real-time release testing of in vitro dissolution and blend uniformity in a continuous powder…
Abstract
Continuous manufacturing is gaining increasing interest in the pharmaceutical industry, also requiring real-time and non-destructive quality monitoring. Multiple studies have already addressed the possibility of surrogate in vitro dissolution testing, but the utilization has rarely been…
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