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Continuous manufacturing
Investing in automated visual inspection and sorting machines: costs, risks and performance…
Introduction
Pharmaceutical companies are increasingly investing in automated visual inspection and sorting machines in order to replace subjective and costly manual sorting. These machines need to efficiently replace human hands by automatic mechanical manipulators, human eyes by digital video…
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Continuous Manufacturing of Solvent-Free Cyclodextrin Inclusion Complexes for Enhanced Drug…
Conventional cyclodextrin complexation enhances the solubility of poorly soluble drugs but is solvent-intensive and environmentally unfavorable. This study evaluated solvent-free hot-melt extrusion (HME) for forming cyclodextrin inclusion complexes to improve the solubility and dissolution of…
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Evaluation of tricalcium citrate as a direct compressible diluent using the SeDeM Expert Diagram…
ABSTRACT
Oral administration of medicine is one of the most common delivery routes still in use today. Various dosage forms are administered via the oral route including tablets, capsules, syrups, solutions and emulsions. Tablets constitute a large part of orally available dosage forms due to ease…
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Advanced process automation of a pharmaceutical continuous wet granulation line: Perspectives on the…
Abstract
Pharmaceutical continuous manufacturing provides the appropriate tools (e.g. the understanding of process dynamics and appropriate and adaptable control strategy) in order to deal with Quality-by-Design expectations and even to the future smart manufacturing described by…
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Continuous Direct Compression of a High-dose Drug Evaluation of Process and Quality Attributes
Summary
Continuous production has now been adopted even in the pharmaceutical industry and is indispensable in current product developments. This study focuses on the process of continuous direct compression, with the aim of guaranteeing constant product quality over the whole production run. A…
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Integrated continuous manufacturing of inhalable remdesivir nanoagglomerate dry powders: design,…
While inhalable nanoparticle-based dry powders have demonstrated promising potential as next-generation respiratory medicines, erratic particle redispersibility, and poor manufacturing reproducibility remain major hurdles hindering their translation from bench to bedside. We developed a one-step…
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Selection of an appropriate tracer to measure the residence time distribution (RTD) of continuous…
Residence time distributions (RTDs) are quickly becoming an important component of the quality control strategy for continuous manufacturing (CM) of pharmaceutical products. However, methodologies for determining RTDs, including appropriate selection of tracers and proper processing of RTD data,…
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Process intensification using a semi-continuous mini-blender to support continuous direct…
The production of pharmaceutical tablets is shifting towards continuous manufacturing. Therefore, individual unit operations such as powder blending need to be re-designed. Continuous powder blending has been implemented successfully, but for low-dose formulations this is challenging due to…
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MicroCoat™: A Breakthrough in Oral Multiparticulate Formulation Development
Oral multiparticulate systems are often the ‘go to’ solution for flexible dosing, especially in cases where a degree of functionality, such as taste masking or modified release, is required from the formulation. One of the preferred methods of adding functionality to multiparticulates is by fluid…
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Pharmaceutical Continuous Manufacturing: Knowledge Center Debuts to Expand Information Access,…
PRESS RELEASE
Rockville, MD, July 11, 2023 – The U.S. Pharmacopeia (USP) and The National Institute for Pharmaceutical Technology and Education (NIPTE) today announced the official launch of their jointly-developed Continuous Manufacturing Knowledge Center (CMKC). The online platform is designed…
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