Disintegrants and superdisintegrant excipients are essential components used in the pharmaceutical industry to enhance the dissolution and bioavailability of active pharmaceutical ingredients (APIs). These excipients facilitate the disintegration and rapid breakup of tablets or capsules, which ultimately increases their rate of absorption in the body.
Pharma Excipients
Disintegrant / Superdisintergrant
Flexible modelling of the dissolution performance of directly compressed tablets
In this study, a compartmental disintegration and dissolution model is proposed for the prediction and evaluation of the dissolution performance of directly compressed tablets. This dissolution model uses three compartments (Bound, Disintegrated, and Dissolved) to describe the state of each particle…
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Croscarmellose Sodium as Pelletization Aid in Extrusion-Spheronization
Only few excipients are known to be suitable as pelletization aids. In this study, the potential use of croscarmellose sodium (CCS) as pelletization aid was investigated. Furthermore, the impact of cations on extrusion-spheronization (ES) of CCS was studied and different grades of CCS were tested.…
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Prediction of in-vitro dissolution and tablet hardness from optical porosity measurements
Abstract
Advanced manufacturing technologies such as continuous processing require fast information on the quality of intermediates and products. Process analytical technologies (PAT) to monitor many critical quality attributes (CQAs) have been developed and successfully implemented in…
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Design of easily swallowable xerogel pill with enough physical strength through hardening-process…
The xerogel pill has been developed as a novel dosage form with dose-adjusting and swallow-assisting functions by using drop freeze-drying (DFD) technique. It was double-structured small sphere composed of an inner drug core and an outer dried-gel layer, however, had problem of insufficient physical…
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Trends in amorphous solid dispersion drug products approved by the U.S. Food and Drug Administration…
Abstract
Forty-eight (48) drug products (DPs) containing amorphous solid dispersions (ASDs) have been approved by the U.S. Food and Drug Administration in the 12-year period between 2012 and 2023. These DPs comprise 36 unique amorphous drugs. Ten (10) therapeutic categories are represented, with…
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Evaluation of binders in twin-screw wet granulation – Optimization of tabletability
Abstract
The influence of hydroxypropyl cellulose type (HPC-SSL SFP, HPC-SSL), concentration (2 %, 3.5 %, 5 %) and filler (lactose, calcium hydrogen phosphate (DCP)/microcrystalline cellulose (MCC)) on twin-screw wet granulation and subsequent tableting was studied. The aim was to identify the…
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Impact of Co-Processing on the Structural Evolution of Lactose and MCC, Investigated by Laboratory…
Introduction
Within the last decades a new subgroup of diluents, so called Co-processed Excipients (CPE), found its way into pharmaceutical practice . After a seemingly endless discussion about their definition, state, and boundaries to a simple physical admixture (PAM), CPE have been defined as a…
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HPMCP – Cellulose derivative for enteric coating by Shin-Etsu
Since the introduction of HPMCP (hypromellose phthalate USP/NF, JP, EP) in 1971, it has proved its value in enteric coating using organic solvent. The chemical structure of HPMCP is a monophthalic acid ester of hypromellose.The threshold pH value for rapid disintegration of HPMCP can be controlled…
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Risperidone/cyclodextrin inclusion complex electrospun nanofibers for fast-disintegrating…
In this paper, the inclusion complexes (ICs) of hydroxypropyl-beta-cyclodextrin (HPβCD) and risperidone were electrospun into nanofibrous film for potential fast-disintegrating drug delivery system. Risperidone is used to treat bipolar disorder, schizophrenia, and mood swings from autism. However,…
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L-HPC – Multifunctional excipient for oral solid dose by Shin-Etsu
L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) was developed by Shin-Etsu and first approved in 1977 as a disintegrant for tablets in Japan. New grades were developed during the last years in order to cover the needs for our customer having best solutions for individual applications.…
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