Formulation and Evaluation of Orodispersible Tablet of Piroxicam by using Natural Polymers

ABSTRACT:

Piroxicam is an oxicam class of NSAID which is a drug of choice in the treatment of severe pains occurs in chronic diseases like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and many more severe conditions. The solid dispersion method with piroxicam were prepared by direct solvent evaporation method using synthetic polymer which was selected though screening of three polymers. The solid dispersion were characterized by FTIR, DSC and evaluated for solubility. The orodispersible tablet of Piroxicam were formulated using homemade banana powder, Locust bean gum, Guar gum, Karaya gum as Superdisintegrant.

The Tablet of piroxicam were evaluated for its physical characters, tablet hardness, weight variation test, friability, drug contents, in vitro drug release and ex-vivo drug release. The solid dispersion method with piroxicam were prepared by direct solvent evaporation method using synthetic polymer which was selected though screening of three polymers. The solid dispersion were characterized by FTIR, DSC and evaluated for solubility. The orodispercible tablet of Piroxicam were formulated using homemade banana powder, Locust bean gum, Guar gum, Karaya gum as Superdisintegrant. The Tablet of piroxicam were evaluated for its physical characters, tablet hardness, weight variation test, friability, drug contents, in vitro drug release and ex-vivo drug release. The formulation F2 found to be showing good results it was optimized. It has shown lesser time in disintegration i.e., 57 Sec.

INTRODUCTION:

Rheumatoid arthritis is an autoimmune and chronic inflammatory disorder that mostly affects the synovial joints and can promote both cartilage and bone tissue destruction. Piroxicam is belongs to NSAID which is used to treatment of arthritis, inflammatory and rheumatic disorders. Piroxicam act by inhibiting Cyclooxygenase 1 and 2 which are act as mediator for production of inflammatory prostaglandins. Oral drug delivery route is one of the most economical and convenient among other drug delivery systems. Children and the elderly Patients faces difficulties in swallowing of tablet and capsules. In such case cases oral therapy become inconvenient which leads to poor patient adherence and may delay in duration of therapy. Such types of issues can be overcome by development of Orodispersible tablets (OTDs) which can be dispersed or dissolved in the small volume of saliva and followed by swallowing with or without water. Additionally, ODTs have potential in enhancement of bioavailability due to faster dissolution rate.

Piroxicam is a BCS class Ⅱ drug with poor aqueous solubility and high permeability, Due to its poor solubility its absorption will become slow and which leads to delayed onset of action. There is a need to improve aqueous solubility of Piroxicam. So important study is solid dispersion of Piroxicam was prepared by solvent evaporations methods using cyclodextrin as carrier. Natural superdisintegrants viz. Banana powder, Locust bean gum, Karaya gum, and Guar gum etc. were used to as Fast disintegration of ODTs. Which show advantages like biocompatibility, lower production cost and more acceptability by the patients.

Hence, in present work an attempt was made to increase the dissolutions rate of Piroxicam by using solid dispersion techniques and by adding potential Natural superdisintegrants.

Read more on ODT of Piroxicam here

Materials:

Piroxicam drug purchased from Yarrow chem Pharma Co. Mumbai, β- Cyclodextrin purchased from Tokyo Chemical Industry. Co. Ltd. Japan. Banana Fruits ware Purchased from Local fruits market, Locust bean purchased from Qvans cure lifesciences Co. Gurugram, Guar gum purchased from Genuine Chemical Co. Mumbai. Karaka gum purchased from Sigma Life Science Co. Ltd. Sangrur, Mannitol and Chloroform purchased from Loba Chemie Pvt.Ltd. Mumbai, Microcrystalline cellulose, Saccharin Sodium, Magnesium Sterate purchased from Research-Lab Fine Chem Industries. Mumbai. Talc purchased from Molychem Co. Ltd. Mumbai.

Bolaj Shrivardhan Mahesh, Rayanade Pooja, Khavare Shital, Chougule Prakash. Formulation and Evaluation of Orodispersible Tablet of Piroxicam by using Natrual Polymers. Asian Journal of Pharmacy and Technology. 2025; 15(1):6-2. doi: 10.52711/2231-5713.2025.00002