Disintegrants and superdisintegrant excipients are essential components used in the pharmaceutical industry to enhance the dissolution and bioavailability of active pharmaceutical ingredients (APIs). These excipients facilitate the disintegration and rapid breakup of tablets or capsules, which ultimately increases their rate of absorption in the body.
Pharma Excipients
Disintegrant / Superdisintergrant
Effect of tableting temperature on tablet properties and dissolution behavior of heat sensitive…
Abstract
The tableting process involves the conversion of mechanical to thermal energy. This study evaluated the influence of temperature on the tableting behavior of formulations with different compositions. The tableting machine was equipped with a thermally controlled die to mimic the heat…
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Effect of magnesium stearate solid lipid nanoparticles as a lubricant on the properties of tablets…
Abstract
This study discusses the lubricant properties of magnesium stearate solid lipid nanoparticles (MgSt-SLN) and their effect on the tabletability, mechanical properties, disintegration, and acetaminophen-model dissolution time of microcrystalline cellulose (MCC) tablets prepared by direct…
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The Development of Oral Solid Dosage Forms Using the Direct-Compression Tableting of Spray-Dried…
Abstract
This study addresses the challenge of developing a cheap, patient-friendly alternative to antibiotics using bacteriophages for gastrointestinal applications. It explores the feasibility of manufacturing an enteric solid dosage form containing a salmonella-specific Myoviridae phage, Felix…
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Determination of Gastric Water Emptying in Fasted and Fed State Conditions Using a…
Abstract
Because of the importance of gastric emptying for pharmacokinetics, numerous methods have been developed for its determination. One of the methods is the salivary tracer technique, which utilizes an ice capsule containing caffeine as a salivary tracer. Despite the ice capsule’s advantage…
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Application on the Direct Encapsulation Method in the Technology of Medicine with Dry Rauwolphia…
Abstract
The aim: Development of the composition and technology of a medicinal drug in the form of capsules with a dry
extract of Rauwolfia for the treatment of hypertension.
Materials and methods: Experimental samples of masses for encapsulation contained 2.0 mg of dry Rauwolfia
extract and…
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In Vivo Evaluation of a Gastro-Resistant Enprotect® Capsule under Postprandial Conditions
Ready-to-fill enteric hard capsule shells are an evolving field of oral drug and nutraceutical products. Lonza Capsugel® Enprotect® capsules were recently proven to provide reliable release in the small intestine after fasted intake, but robustness against postprandial intake needed to be proven. In…
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Roquette Introduced New Chapter in Moisture Protection at CPhI 2023
Press Release
La Madeleine (France), 25th October 2023 – Roquette, a global leader in plant-based ingredients and leading provider of pharmaceutical and nutraceutical excipients, is pleased to announce the addition of three new excipient grades to its unmatched portfolio of solutions for moisture…
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Fast time-resolved micro-CT imaging of pharmaceutical tablets: Insights into water uptake and…
Abstract
We use dynamic micro-computed tomography (micro-CT) with a high temporal resolution to visualize water penetration through the porous network of immediate-release pharmaceutical solid tablets and characterize dynamic swelling and disintegration mechanisms. We process the micro-CT images…
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Application of Response Surface Methodology to Improve the Tableting Properties of Poorly…
Designing a robust direct compression (DC) formulation for an active pharmaceutical ingredient (API) with poor flow and compaction properties at a high API load is challenging. This study tackled two challenges: the unfavorable flow characteristics and tableting problems associated with a…
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The Impact of Polymer Mixture Composition on the Properties of Electrospun Membranes for Drug…
Orally dispersible films (ODFs) prepared by an electrospinning are a novel type of pharmaceutical formulation. This dosage form has the potential to be beneficial for small children and the elderly, who can have problems with administration of classical tablets due to the increased risk of choking…
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