Efficient skin delivery with Transcutol P

Transcutol® P is a high purity grade of diethylene glycol monoethyl ether (DEGEE) manufactured by the condensation of ethylene oxide and ethanol, followed by distillation. The presence of an ether and an alcohol function explains the exceptional solubilizing capacity of this solvent.

A powerful solubilzer
A key feature of Transcutol® P is its solubilization capacity for both lipophilic and hydrophilic APIs. Figure 3 gives saturation solubility data of a wide set of APIs used in topical drug delivery.

Increasing drug solubility in the vehicle, and thereby the thermodynamic driving force, provides higher diffusion and better skin permeation. Formulating with Transcutol® P ensures sufficient drug solubilization and subsequent delivery of an adequate concentration at the target site.


An efficient penetration and permeation enhancer
The mechanism of action of Transcutol® P for penetration and permeation enhancement can be explained as follows:

  • Increasing drug solubility in the vehicle
  • Decreasing drug charge by a solvent effect
  • Increasing drug solubility and partitioning in the stratum corneum
  • Maintaining hydrated dynamics in the stratum corneum without disturbing the lipid bilayer structures

For more information download the product information here: Brochure Transcutol P for efficient skin penetration

Further product information on Gattefossé products

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