Pharma Excipients
Emulsifier
Preparation of Nanosized Pharmaceutical Formulations by Dual Centrifugation
Abstract
Dual centrifugation (DC) is an innovative in-vial homogenization and in-vial nanomilling technique that has been in use for the preparation of liposomes for more than one decade. Since then, DC has continuously been developed for preparing various liposomes and other lipid nanoparticles…
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The Anti-Oxidant Curcumin Solubilized as Oil-in-Water Nanoemulsions or Chitosan Nanocapsules…
Abstract
The bacterium Helicobacter pylori (H. pylori) represents a major risk factor associated with the development of gastric cancer. The anti-oxidant curcumin has been ascribed many benefits to human health, including bactericidal effects. However, these effects are poorly reproducible because…
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Modern Aspects of Suppositories: A Review
ABSTRACT
Suppositories are an underutilized dosage form. Suppositories are such types of dosage forms used to provide medication via the vaginal and rectal routes. Vaginal suppositories are commonly referred to as pessaries. It was
developed from a formulation called Liquid Enema. Enema has a…
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Enhanced in vivo absorption and biodistribution of curcumin loaded into emulsions with high…
The health benefits of curcumin have been demonstrated by clinical studies, but its low bioavailability compromises its functionality. In this regard, emulsions have proven to be effective encapsulation systems for curcumin. Nevertheless, emulsions with a high oil content (50%) may offer some…
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Nanosuspensions as carriers of active ingredients: Chemical composition, development methods, and…
Nanosuspensions (NSps) are colloidal dispersions of particles that have the potential to solve the delivery problems of active ingredients associated with their low solubility in water or instability due to environmental factors. It is essential to consider their chemical composition and preparation…
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The synthesis of certain fatty acid ester derivatives of trehalose and an investigation of their…
Bio-based surfactants exerting both functional and nutritional properties are needed in the food industry. This study reports the one-pot synthesis, using a Novozym 435-catalyzed trans-esterification protocol, of a new family of such compounds, namely a homologous series of 6-O-acylated trehalose …
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Bacteriophage entrapped chitosan microgel for biofilm-mediated poly bacterial infection in burn…
Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) bacteria are most commonly present in burn wound infections. Multidrug resistance (MDR) and biofilm formation make it difficult to treat these infections. Bacteriophages (BPs) are proven as an effective therapy against MDR…
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Influence of Poloxamer 188 on Anti-Inflammatory and Analgesic Effects of Diclofenac-loaded…
Abstract
In this study, a polymer-stabilized nanoemulsion (PNE) was developed to improve the inflammatory and analgesic activities of diclofenac (DA). DA-PNEs were prepared from sesame oil and poloxamer 188 (P188), polysorbate 80, and span 80 as emulsifiers and optimized by a systematic…
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Safety of Surfactant Excipients in Oral Drug Formulations
Abstract
Surfactants are a diverse group of compounds that share the capacity to adsorb at the boundary between distinct phases of matter. They are used as pharmaceutical excipients, food additives, emulsifiers in cosmetics, and as household/industrial detergents. This review outlines the…
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A quality by design framework for developing nanocrystal bioenabling formulations
The present study aims to outline a rational framework for the design and development of a 1.0% (w/v) hydrocortisone nanocrystal-based formulation, resorting to a simple, efficient, and scalable nanonization methodology, based on the high-pressure homogenization (HPH) technique. Accordingly, the…
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