CarboHyde

Company profile

About CarboHyde

CarboHyde is a private preclinical pharmaceutical company redefining industries through the unparalleled potential of cyclodextrins. We are a team of passionate cyclodextrin experts who believe that targeted industrial experience is essential to advance and broaden innovative projects.

We support projects from early development to commercialization by combining cyclodextrin chemistry, formulation expertise, analytical characterization and product development.

Cyclodextrin-Based Solutions

Cyclodextrins provide versatile tools for addressing formulation challenges such as poor solubility, limited stability and low bioavailability, while also enabling more advanced drug delivery applications.

Our purpose is to bring cyclodextrin-based innovations to the market.

Tamás Sohajda, CEO

What We Offer

Custom Synthesis

CarboHyde develops custom cyclodextrin derivatives and specialized intermediates for specific applications. Our capabilities span laboratory-scale synthesis, structural characterization, route development and optimization, scale-up support, novel derivative design and the troubleshooting of challenging synthetic routes.

We support projects from research compounds toward scalable synthetic processes and can provide custom cyclodextrin and carbohydrate synthesis as part of this development pathway. We also support clients in developing scalable synthetic routes and preparing projects for subsequent GMP manufacturing.

Formulation Development

CarboHyde combines cyclodextrin chemistry with pharmaceutical formulation expertise to develop workable formulations for challenging APIs.

Our support includes pre-formulation studies, excipient and carrier selection, formulation optimization, solid and liquid dosage-form development, and troubleshooting or reformulation of existing products. Depending on the molecule and application, formulation development may also focus on improving solubility, stability and bioavailability.

Cyclodextrin Complexes

Cyclodextrins can form inclusion complexes with suitable guest molecules, enabling improvements in aqueous solubility, dispersibility, physical and chemical stability and formulation compatibility. Complexation can also help protect sensitive active ingredients, support taste and odor masking and enable innovative dosage forms.

Our expertise covers α-, β- and γ-cyclodextrins as well as modified derivatives, allowing selection of the most appropriate cyclodextrin system for the individual molecule and application.

Analytics

Reliable analytical data is essential for understanding molecular structure, complex formation, purity and formulation performance. CarboHyde provides analytical support across both cyclodextrin chemistry and formulation development.

Our activities include structural characterization, identification of cyclodextrin derivatives, characterization of cyclodextrin–guest complexes, analytical method development, formulation and product characterization, elemental impurity analysis using ICP-MS and ICP-OES, and stability studies. Our current offering also includes bioanalytical methods for safety and Drug Metabolism and Pharmacokinetics support.

Cyclodextrin Technologies & Offerings

Cyclodextrin Polymers

Crosslinked cyclodextrin materials with high binding capacity can be applied in areas including drug delivery, purification and controlled release.

Cyclodextrins as APIs

Beyond their traditional role as excipients, cyclodextrins can also be developed as therapeutic molecules, opening new possibilities for active pharmaceutical applications.

Custom Cyclodextrin Derivatives

When standard cyclodextrins do not provide the required properties, tailored derivatives can be designed for the target molecule and application, with optimization for properties such as solubility, stability and molecular recognition.

Novel Source of γ-Cyclodextrin

CarboHyde is developing a versatile γ-cyclodextrin platform whose larger molecular cavity enables the complexation of larger and more challenging APIs.

Fluorescent Cyclodextrins

Fluorescently labelled cyclodextrins provide tools for imaging, tracking and interaction studies in research and diagnostic applications.

Cyclodextrins for Sustained Release

Cyclodextrin systems can be engineered for prolonged drug release, with the aim of improving therapeutic performance and dosing profiles.

Cyclodextrin–API Conjugates

Covalent conjugates of cyclodextrins and active pharmaceutical ingredients provide a platform for targeted and advanced drug delivery applications.

Cyclodextrins for Gene Delivery

Functionalized cyclodextrins can act as non-viral carriers for nucleic acids and can be designed for DNA and RNA delivery.

Cyclodextrins for Protein Stabilization

Cyclodextrins can support protein stability during formulation and storage, helping reduce aggregation and improve formulation robustness.

Cyclodextrins as Vaccine Adjuvants

Cyclodextrin-based platforms can support antigen delivery and immune modulation in the development of next-generation vaccine technologies.

Service Area

Unstable Proteins

Cyclodextrin-based stabilization of proteins and monoclonal antibodies to reduce aggregation, control viscosity, and enable robust injectable formulations.

Taste Masking

Cyclodextrin-based taste and odor masking to improve palatability while preserving release, stability, and product performance.

Medicinal Chemistry

Custom cyclodextrin design and development, from molecular concept and synthesis to scalable, patentable, and industrially viable products.

Analytical Chemistry

Specialized analytical support for cyclodextrins and their complexes, from release testing and method development to binding, stability, and structural characterization.