Hot-melt extrusion

Abstract Contemporary small-molecule drug candidates increasingly have limited aqueous solubility, rendering oral delivery challenging. Amorphous solid dispersions (ASDs) and lipid-based...

Abstract Delamanid, an antituberculosis drug used for multidrug-resistant tuberculosis, has extremely poor water solubility and a high melting point of...

Abstract Kollidon® SR of low (KoL) or high (KoH) moisture content was hot-melt extruded with sorbitol (SOR). Microhardness of KoL/SOR...

Abstract Insufficient aqueous dissolution properties constitute a fundamental barrier impacting approximately 40% of commercialized and 90% developmental pharmaceuticals, significantly limiting...

Abstract This study explores the impact of drug loading (DL) on the physical stability, dissolution performance, and micellisation behaviour of...

Abstract Poor tablet hardness and drug re-crystallization are two common challenges of amorphous solid dispersion (ASD) formulations prepared with hot-melt...

Abstract Although FDM is one of the prominent 3D printing technologies, and it has been widely investigated in pharmaceutical sciences,...

Abstract Background: Three-dimensional (3D) printing has been established in pharmaceutical sciences for preparing customized dosage forms with intricate release profiles....

Abstract For young patients, medicated chocolates and medicated lollipops are quite appropriate dose forms because traditional formulations like tablets and...

This study explores a novel acid-base supersolubilization (ABS) principle for enhancing the solubility and dissolution rate of indomethacin, a poorly...