Amorphous Solid Dispersions: Role of the Polymer and Its Importance in Physical Stability and In Vitro Performance

30. August 2022

Amorphous solid dispersions stabilized by one or more polymer(s) have been widely used for delivering amorphous drugs with poor water...

3D printing of bioactive materials for drug delivery applications

23. August 2022

Introduction Three-dimensional (3D) printing, also known as additive manufacturing (AM), is a modern technique/technology, which makes it possible to construct...

Moisture Sorption by Polymeric Excipients Commonly Used in Amorphous Solid Dispersions and its Effect on Glass Transition Temperature: II. Cellulosic Polymers

16. August 2022

Moisture sorption by polymeric carriers used for the development of amorphous solid dispersions (ASDs) plays a critical role in the...

Immediate release 3D printed oral dosage forms: How different polymers have been explored to reach suitable drug release behaviour

10. August 2022

Three-dimensional (3D) printing has been gaining attention as a new technological approach to obtain immediate release (IR) dosage forms. The...

Fabrication of bilayer tablets using hot melt extrusion-based dual-nozzle fused deposition modeling 3D printing

11. July 2022

The objective of this study was to fabricate bilayer tablets using hot-melt extrusion (HME)-based dual-nozzle fused deposition modeling (FDM) three-dimensional...

Downstream Processing of Itraconazole:HPMCAS Amorphous Solid Dispersion: From Hot-Melt Extrudate to Tablet Using a Quality by Design Approach

8. July 2022

The downstream processing of hot-melt extruded amorphous solid dispersions (ASDs) into tablets is challenging due to the low tabletability of...

Preparation of Decoquinate Solid Dispersion by Hot-Melt Extrusion as an Oral Dosage Form Targeting Liver-Stage Plasmodium Infection

13. June 2022

Liver-stage Plasmodium in humans is an early stage of malarial infection. Decoquinate (DQ) has a potent multistage antimalarial activity. However, it is...

Compression Modulus and Apparent Density of Polymeric Excipients during Compression—Impact on Tabletability

26. April 2022

The present study focuses on the compaction behavior of polymeric excipients during compression in comparison to nonpolymeric excipients and its...

Scaling up Aqueous Enteric Coating with Hypromellose Acetate Succinate (HPMCAS) – Scientific poster

11. April 2022

The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at...

Designing highly porous amorphous celecoxib particles by spray freeze drying leads to accelerated drug absorption in-vivo

30. March 2022

Poorly water-soluble drugs are still a major challenge to overcome in order to achieve sufficiently high oral bioavailability. Spray freeze...

HPMCAS - Hydroxypropyl methylcellulose acetate succinate