Browsing Category
Lactose
Evaluation of binders in twin-screw wet granulation – Optimal combination of binder and disintegrant
The influence of localization (intragranular, split or extragranular) of three superdisintegrants (croscarmellose sodium, crospovidone, sodium starch glycolate) on granules and tablets after twin-screw granulation was studied. The aim was to find a suitable disintegrant type and disintegrant…
Read More...
Read More...
Investigating the Influence of HPMC K4M and Eudragit L 100-55 on Guanfacine-Loaded Extended-Release…
This study aims to optimize the concentrations of hydroxypropyl methyl cellulose (HPMC) K4M and Eudragit L100- 55 (methacrylic acid) in formulation of extended-release tablets containing guanfacine hydrochloride by employing a 32 -factorial design approach. Extended-release tablets of guanfacine…
Read More...
Read More...
Effect of Process Parameters, Protectants and Carrier Materials on the Survival of Yeast Cells…
The administration of living microorganisms is of special interest, with regard to probiotic microorganisms providing health benefits to the patient. Effective dosage forms require the preservation of microbial viability until administration. Storage stability can be improved by drying, and the…
Read More...
Read More...
Smart specification setting for dry powder inhalation carriers
The specifications of excipients are important to pharmaceutical manufacturers to ensure that the final product can be manufactured robustly over the entire lifecycle of a drug product. Particle size specifications are key for dry powder inhalation excipients and they should be agreed between users…
Read More...
Read More...
Predicting pharmaceutical powder flow from microscopy images using deep learning
The powder flowability of active pharmaceutical ingredients and excipients is a key parameter in the manufacturing of solid dosage forms used to inform the choice of tabletting methods. Direct compression is the favoured tabletting method; however, it is only suitable for materials that do not show…
Read More...
Read More...
Downstream processing of amorphous solid dispersions into tablets
Amorphous solid dispersions have gained tremendous attention as a commercially viable solubility enhancement technique for poorly water-soluble drugs. However, poor drug loading associated with poor drug-polymer miscibility is a major challenge in the downstream processing of ASDs. While many…
Read More...
Read More...
Behaviour of magnesium stearate at particle–particle interfaces: Microdynamic flowability to monitor…
Monitoring magnesium stearate (MgSt) surface coverage remains a challenge in powders. Microdynamic flowability is proposed to better understand the nature of these films and how formulation and process variability affect the final product. The method examined small-scale particulate solids in motion…
Read More...
Read More...
High-Shear Granulation of Hygroscopic Probiotic-Encapsulated Skim Milk Powder: Effects of…
A fine, hygroscopic, and poorly flowable probiotic powder encapsulating Lactobacillus rhamnosus GG (LGG) was granulated using a high-shear granulation process, wherein a small amount of water (4%, w/w) was used for moisture-activation with or without 10% (w/w) resistant maltodextrin (RM). The…
Read More...
Read More...
Celecoxib Nanoformulations with Enhanced Solubility, Dissolution Rate, and Oral Bioavailability:…
Celecoxib (CXB) is a Biopharmaceutical Classification System (BCS) Class II molecule with high permeability that is practically insoluble in water. Because of the poor water solubility, there is a wide range of absorption and limited bioavailability following oral administration. These unfavorable…
Read More...
Read More...
Surface Modification of Lactose Carrier Particles Using a Fluid Bed Coater to Improve Fine Particle…
Surface roughness of carrier particles can impact dry powder inhaler (DPI) performance. There are opposing views on the effect of roughness on DPI performance. Hence, a systematic approach is needed to modify carrier surfaces and evaluate the impact on drug delivery. Carrier particle surfaces were…
Read More...
Read More...