Browsing Category
Lactose
The micro-structure of lactose powder compacts studied by small-angle and ultra small-angle X-ray…
Abstract
The objective was to derive indications of the microstructure of lactose powder compacts was studied by small-angle and ultra small-angle X-ray scattering experiments (SAXS/USAXS). Measurements were performed on a series of lactose powder compacts formed at four different pressures in the…
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Comparison of granules obtained with two twin-screw granulators of different diameter working at the…
Abstract
We study the response of two twin-screw granulators of different barrel diameter to the variation of three process parameters (liquid-to-solid ratio, screw speed and throughput), while maintaining the same shear rate field along the screws. Various responses, including size distribution,…
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Impact of pharmaceutical tablet properties on optical porosimetry performance
Abstract
The porosity of a pharmaceutical tablet influences liquid transport, disintegration and dissolution, rendering its monitoring and control crucial for quality by design. Optical porosimetry, a non-destructive process analytical technology (PAT), combines gas in scattering media absorption…
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Manufacturing softpellets using triboelectric agglomeration of fine powders on a vibrated inclined…
Abstract
Fine powders are required in many industrial applications, but their poor flow properties make handling and processing challenging. In Dry Powder Inhalation (DPI), for instance, inhaled particles must have an aerodynamic diameter between 1 and 5 μm to ensure therapeutic efficiency.…
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Study of the Influence of Pharmaceutical Excipients on the Solubility and Permeability of BCS Class…
Abstract
Most novel active pharmaceutical ingredients have low water solubility; therefore, solubility-enhancing methods are applied. The aim of the present investigation is to study the impact of nine commonly used pharmaceutical excipients (fillers, surfactants, cyclodextrins, polymers) on…
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Effect of additives and operating conditions on tablet weight variation: Analysis based on powder…
Abstract
The flowability and compressibility of powders during tableting are crucial for determining the quality of pharmaceutical products. Although silicon compounds are additives that improve compressibility, their type and addition ratio could impair flowability. Therefore, formulation and…
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Does tablet shape and height influence survival of fluidized bed-granulated living microorganisms…
Abstract
The provision of effective probiotic formulations requires gentle processing to maintain the viability of the probiotic microorganisms, which is essential for their health-promoting effects. The drying of microorganisms by fluidized bed spray granulation and subsequent processing of the…
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Veterinary soft chews using Gelucire® 50/13 and Precirol® ATO 5 – ECP 2025 Poster
This poster was presented at the ECP 2025 in Porto
A proof of concept with wet extrusion
Introduction
Veterinary soft chews are gaining interest among oral dosage forms for companion animals as they provide good acceptance for the pet and are easy to administrate by the pet owner,…
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Thermal Analysis of Lactose Polymorphs – ECP 2025 Poster
This poster was presented at the ECP 2025 in Porto
Introduction
The following polymorphic forms of lactose exist: α-Lactose Monohydrate (α-LMH), α-Lactose Anhydrous (α-LA) stable, α-LA unstable, β-Lactose Anhydrous (ß-LA) and amorphous Lactose (Lamorph). α-LMH is the thermodynamically most…
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Risk Mitigation of Nitrosamines Formation in Drug Products: Role of Excipients – Interview with…
MEGGLE published a study and an update on the topic of "Risk Mitigation of Nitrosamines Formation in Drug Products: Role of Excipients” in 2024.
Pharma Excipients interviewed Dr. Spellerberg from MEGGLE about the background and most important topics and findings of the study.
The…
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