Lactose

Abstract The objective was to derive indications of the microstructure of lactose powder compacts was studied by small-angle and ultra small-angle X-ray scattering experiments (SAXS/USAXS). Measurements were performed on a series of lactose powder compacts formed at four different pressures in the…
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Abstract We study the response of two twin-screw granulators of different barrel diameter to the variation of three process parameters (liquid-to-solid ratio, screw speed and throughput), while maintaining the same shear rate field along the screws. Various responses, including size distribution,…
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Abstract The porosity of a pharmaceutical tablet influences liquid transport, disintegration and dissolution, rendering its monitoring and control crucial for quality by design. Optical porosimetry, a non-destructive process analytical technology (PAT), combines gas in scattering media absorption…
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Abstract Fine powders are required in many industrial applications, but their poor flow properties make handling and processing challenging. In Dry Powder Inhalation (DPI), for instance, inhaled particles must have an aerodynamic diameter between 1 and 5 μm to ensure therapeutic efficiency.…
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Abstract Most novel active pharmaceutical ingredients have low water solubility; therefore, solubility-enhancing methods are applied. The aim of the present investigation is to study the impact of nine commonly used pharmaceutical excipients (fillers, surfactants, cyclodextrins, polymers) on…
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Abstract The flowability and compressibility of powders during tableting are crucial for determining the quality of pharmaceutical products. Although silicon compounds are additives that improve compressibility, their type and addition ratio could impair flowability. Therefore, formulation and…
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Abstract The provision of effective probiotic formulations requires gentle processing to maintain the viability of the probiotic microorganisms, which is essential for their health-promoting effects. The drying of microorganisms by fluidized bed spray granulation and subsequent processing of the…
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This poster was presented at the ECP 2025 in Porto A proof of concept with wet extrusion Introduction Veterinary soft chews are gaining interest among oral dosage forms for companion animals as they provide good acceptance for the pet and are easy to administrate by the pet owner,…
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This poster was presented at the ECP 2025 in Porto Introduction The following polymorphic forms of lactose exist: α-Lactose Monohydrate (α-LMH), α-Lactose Anhydrous (α-LA) stable, α-LA unstable, β-Lactose Anhydrous (ß-LA) and amorphous Lactose (Lamorph). α-LMH is the thermodynamically most…
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MEGGLE published a study and an update on the topic of "Risk Mitigation of Nitrosamines Formation in Drug Products: Role of Excipients” in 2024. Pharma Excipients interviewed Dr. Spellerberg from MEGGLE about the background and most important topics and findings of the study.  The…
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