Charge converting nanostructured lipid carriers containing a cell-penetrating peptide for enhanced cellular uptake

5. August 2022

Hypothesis The aim of this study was the development of nanostructured lipid carriers (NLCs) decorated with a polycationic cell-penetrating peptide (CPP). A...

PEGylated SLN as a Promising Approach for Lymphatic Delivery of Gefitinib to Lung Cancer

3. August 2022

Purpose: The present study aimed to develop gefitinib-loaded solid lipid nanoparticles (GEF-SLN), and GEF-loaded PEGylated SLN (GEF-P-SLN) for targeting metastatic lung...

Nose to brain delivery of melatonin lipidic nanocapsules as a promising post-ischemic neuroprotective therapeutic modality

3. August 2022

Ischemic stroke accounts for about 87% of all strokes, causing long-term disability in adults, and is the second leading cause...

Lipid nanocapsules for intracellular delivery of microRNA: A first step towards intervertebral disc degeneration therapy

2. August 2022

Approximately 40% of cases of lower back pain are caused by disc degeneration disease (DDD). It is well established that microRNA (miR) dysregulation is...

Compritol-Based Nanostrucutured Lipid Carriers (NLCs) for Augmentation of Zolmitriptan Bioavailability via the Transdermal Route: In Vitro Optimization, Ex Vivo Permeation, In Vivo Pharmacokinetic Study

26. July 2022

Migraine is a severe neurovascular disease manifested mainly as unilateral throbbing headaches. Triptans are agonists for serotonin receptors. Zolmitriptan (ZMP)...

Design, characterization and in vivo performance of solid lipid nanoparticles (SLNs)-loaded mucoadhesive buccal tablets for efficient delivery of Lornoxicam in experimental inflammation

20. July 2022

Lornoxicam (LRX) is a potent nonsteroidal anti-inflammatory drug (NSAID) used extensively to manage pain and inflammatory conditions. However, the drug possesses...

Standardization of an in vitro assay matrix to assess cytotoxicity of organic nanocarriers: a pilot interlaboratory comparison

16. July 2022

Nanotechnologies such as nanoparticles are established components of new medical devices and pharmaceuticals. The use and distribution of these materials...

Development of a long-acting tablet with ticagrelor high-loaded nanostructured lipid carriers

15. July 2022

Ticagrelor (TCG), an antiplatelet agent, has low solubility and permeability; thus, there are many trials to apply the pharmaceutical technology...

Non-invasive drug delivery systems mediated by nanocarriers and molecular dynamics simulation for posterior eye disease therapeutics: Virtual screening, construction and comparison

14. July 2022

Local deliver medication in a non-invasive pattern and attaining a long-term sustained release at ocular regions to minimize side effects...

Multifunctional active ingredient-based delivery systems for skincare formulations: A review

9. July 2022

Nowadays, there is a growing demand for effective cosmetic skincare products that can address the specific skin problems of consumers....

Lipid Nanoparticles