Liquids

Abstract We study the response of two twin-screw granulators of different barrel diameter to the variation of three process parameters (liquid-to-solid ratio, screw speed and throughput), while maintaining the same shear rate field along the screws. Various responses, including size distribution,…
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Abstract With continued interest in high concentration monoclonal antibody drug products to meet subcutaneous administration requirements, there is heightened attention on balancing protein-protein interactions, solution properties and overcoming instabilities such as increased in viscosity,…
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This poster was presented at the ECP 2025 in Porto A proof of concept with wet extrusion Introduction Veterinary soft chews are gaining interest among oral dosage forms for companion animals as they provide good acceptance for the pet and are easy to administrate by the pet owner,…
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Abstract Film-forming solution (FFS) implies a novel formulation strategy for liquid preparations for cutaneous application with numerous advantages in comparison with compendial dosage forms, including flexibility of composition (active pharmaceutical ingredient (API) solution in volatile and…
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Introduction Self-emulsifying drug delivery systems (SEDDS) have emerged as a promising approach for enhancing the oral bioavailability of challenging therapeutic compounds, particularly biopharmaceuticals like proteins and peptides. A study published in “Pharmaceutics” journal showcases an…
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AQUAPOL Thickening and gelling agent The AQUAPOL line of “Acrylates polymers” is a synthetic high molecular weight cross-linked water-soluble polymer of acrylic acid. The cosmetic, pharmaceutical, and home industries all use it extensively. It comes as a liquid or powder and is soluble in water,…
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Abstract Background/Objectives: Thickened waters are commonly used for dysphagic patients to ensure hydration, facilitate safer swallowing, and administer oral therapies, yet their impact on drug dissolution remains unclear. This study aims to investigate how thickening agents, viscosity, and solid…
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KLK Kolb excipients, marketed under the Hedjuvan brand, are all produced at the Hedingen facility in Switzerland. These versatile excipients find extensive use in human, veterinary and biopharmaceutical industry. As surfactants, they play a crucial role in surface-to-surface interactions, including…
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AQUAPOL Thickening and gelling agent The AQUAPOL line of “Acrylates polymers” is a synthetic high molecular weight cross-linked water-soluble polymer of acrylic acid. The cosmetic, pharmaceutical, and home industries all use it extensively. It comes as a liquid or powder and is soluble in water,…
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Abstract It is desirable but remains challenging to develop high drug load amorphous solid dispersions (ASDs) without compromising their quality attributes and bio-performance. In this work, we investigated the impacts of formulation variables, such as drug loading (DL) and polymer type, on…
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