Liquids

Abstract Temozolomide (TMZ) is part of the therapeutic armamentarium used in managing pediatric cancers; however, available oral forms (capsules) are not adapted for use in children. Our aim was to assess the dose accuracy and stability of TMZ using capsule contents mixed with food compared with a…
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The desired end product properties can make a difference when choosing between spray drying or spray granulation Both spray drying and fluid bed spray granulation can be used to convert liquid products into bulk materials. The most effective process will often be dictated by the desired properties…
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Abstract Cannabidiol (CBD) has been recognized for its numerous therapeutic benefits, such as neuroprotection, anti-inflammatory effects, and cardioprotection. However, CBD has some limitations, including unpredictable pharmacokinetics and low oral bioavailability. To overcome the challenges…
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1. Introduction Solid dispersion is one of the most effective technologies to improve API characteristics such as solubility, stability, and compressibility. Recently developed small molecule APIs with the aim to higher therapeutic effects, tend to become poor soluble, as much as 70% or higher…
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Introduction Several major active ingredients for human health, such as vitamin A/D/E/K, DHA/EPA, and natural herbal extracts are supplied in liquid form. Emulsified powder and microencapsulation were previously known as the major ways to provide better compatibility with other ingredients, but…
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1. Introduction Many liquid active ingredients are supplied in a soft-gel capsule form, because a soft gel capsule is easy to release control and can avoid formulation difficulties. However, it has serious weakness in stability, especially in humid environments; swallowability in the elder people,…
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Carvedilol (CARV) is an ‘off-label’ β-blocker drug to treat cardiovascular diseases in children. Since CARV is nearly insoluble in water, only CARV solid forms are commercialized. Usually, CARV tablets are manipulated to prepare an extemporaneous liquid formulation for children in hospitals. We…
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Lipid liquid crystalline nanoparticles (LCNPs) are unique nanocarriers that efficiently deliver antimicrobials through biological barriers. Yet, their wide application as an antimicrobial delivery system is hindered by their poor stability in aqueous dispersions. The production of dried LCNP powder…
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Introduction Historically known as “the disease of kings,” gout is one of the oldest known types of arthritis, affecting more than 40 million people worldwide, prevalent in patients between 30 and 50 years of age, and frequently experienced more by males than females , , , ]. It is a result of…
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Kolliphor® CSL (cetostearyl alcohol, sodium lauryl sulfate, and sodium cetostearyl sulfate) by BASF is an emulsifier and structuring agent combination product that is suitable for O/W (oil-in-water) formulations. Its strategically designed self-emulsifying properties allow it to be used in…
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