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Maltodextrin
Assessment of the protective potential of coated microparticles in a fluidized bed against the…
Abstract
A strategy to enhance the protective effect of bioactive compounds in spray-dried microparticles is fluidized bed coating. Linseed oil was previously microencapsulated by spray drying using maltodextrin and whey protein as wall materials, and then coated with hydroxypropyl…
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A Mini-Review on Enhancing Solubility in Topical Hydrogel Formulations Using Solid Dispersion…
Abstract
The solubility behavior of drugs is a critical factor in formulation development. Approximately 40–45% of new drugs face market entry challenges due to low water solubility. Enhancing drug bioavailability is thus essential in developing pharmaceutical dosage forms. Many biopharmaceutical…
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Toward the Optimal Choice of Gelled Vehicles for Oral Drug Administration in Dysphagic Patients
Abstract
Background/Objectives: Thickened waters are commonly used for dysphagic patients to ensure hydration, facilitate safer swallowing, and administer oral therapies, yet their impact on drug dissolution remains unclear. This study aims to investigate how thickening agents, viscosity, and solid…
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Encapsulation of Ibuprofen by Pickering-Stabilized Antibubbles
Abstract
Ibuprofen, one of the most widely used nonsteroidal anti-inflammatory drugs, is a poor-tasting and poorly soluble drug. As an alternative approach to overcome these issues, ibuprofen was encapsulated in Pickering antibubbles using two different oils, cyclomethicone and cyclooctane, as…
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A comparative study of two data-driven modeling approaches to predict drug release from ER matrix…
Abstract
The pharmaceutical industry is striving to develop innovative and promising tools, increasingly embracing new data-driven approaches, to understand, improve and accelerate the drug product development process. While extended release (ER) oral formulations offer a number of advantages,…
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The pharmaceutical quality of freeze-dried tablets containing therapeutic bacteriophages against…
Abstract
The preparation of a solid dosage form containing bacteriophages, which meets pharmaceutical requirements and ensures long-term stability of the phage effect, is significant for implementing phage therapy in practice. A commonly used method for processing phages into a solid form is…
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Design and evaluation of solid self-nanoemulsifying drug delivery systems of cyclosporine developed…
Abstract
Cyclosporine (CYC) is a drug that belongs to the BCS class II category. This study was designed to develop novel solid self-nanoemulsifying drug delivery systems (S-SNEDDS) for cyclosporine (CYC), using chitosan–EDTA microparticles. Such microparticles are known to exhibit superior…
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3D printed personalized therapies for pediatric patients affected by adrenal insufficiency
ABSTRACT
Background
Adrenal insufficiency is usually diagnosed in children who will need lifelong hydrocortisone therapy. However, medicines for pediatrics, in terms of dosage and acceptability, are currently unavailable.
Research design and methods
Semi-solid extrusion (SSE) 3D printing…
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Comparative Study of Spray-Drying and Freeze-Drying Techniques for Increasing Fenofibrate’s…
Abstract
Background: Fenofibrate (FF) is a BCS class II compound whose poor solubility poses challenges in drug delivery and bioavailability. Solid self-micro emulsifying drug delivery systems (S-SMEDDS) have emerged as a promising solution to address these issues. These systems are aimed at…
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Investigation of Stabilized Amorphous Solid Dispersions to Improve Oral Olaparib Absorption
In this study, we investigated the formulation of stable solid dispersions to enhance the bioavailability of olaparib (OLA), a therapeutic agent for ovarian cancer and breast cancer characterized as a BCS class IV drug with low solubility and low permeability. Various polymers were screened based on…
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