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Maltodextrin
Microbiota-sensitive drug delivery systems based on natural polysaccharides for colon targeting
Colon targeting is an ongoing challenge, particularly for the oral administration of biological drugs or local treatment of inflammatory bowel disease (IBD). In both cases, drugs are known to be sensitive to the harsh conditions of the upper gastrointestinal tract (GIT) and, thus, must be protected.…
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Taste Detection of Maltooligosaccharides with Varying Degrees of Polymerization
Previous studies have shown that humans can taste maltooligosaccharides but not maltopolysaccharides (MPS; DP of >20) and that their taste detection is independent of the canonical sweet taste receptor. The objectives of this study were to determine the DP ranges of target stimuli that are…
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Impact of matrices composition and processes on β-galactosidase encapsulation
Advances in existing drying techniques are essential for upgrading large scale industries. Enzymes are often degraded by drying processes. Spray drying (SD) has detrimental effects on bioactive molecules at high temperatures. Freeze-drying (FD) is a reference technique capable of drying sensible…
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A review on the colours, flavours and shapes used in paediatric 3D printed oral solid dosage forms
Abstract
Objectives
This review aims at gleaning the currently available research reports that relate to 3D printlets for paediatric patients, and especially the excipients used to produce various colours, flavours, shapes and sizes.
Methods
A thorough literature review on paediatric 3D printed…
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High-Shear Granulation of Hygroscopic Probiotic-Encapsulated Skim Milk Powder: Effects of…
A fine, hygroscopic, and poorly flowable probiotic powder encapsulating Lactobacillus rhamnosus GG (LGG) was granulated using a high-shear granulation process, wherein a small amount of water (4%, w/w) was used for moisture-activation with or without 10% (w/w) resistant maltodextrin (RM). The…
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Study of the dextrose equivalent of maltodextrins in electrospinning using an ethanol/water mixture…
Maltodextrin (MD) is a natural polymer ideal for electrospinning due to its non-toxicity, water solubility, and low viscosity. In this investigation, MD solutions, each containing a different dextrose equivalent (DE) value of 18, 10, and 4, were studied in an ethanol/water solvent system for the…
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Using a Material Library to Understand the Change of Tabletability by High Shear Wet Granulation
Understanding the tabletability change of materials after granulation is critical for the formulation and process design in tablet development. In this paper, a material library consisting of 30 pharmaceutical materials was used to summarize the pattern of change of tabletability during high shear…
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Physical stability of co-freeze-dried powders made from NaCl and maltodextrins – Impact of NaCl on…
NaCl is commonly added into food powders as a humectant or taste enhancer with little consideration of its impact on the physical properties and stability of powders. In this study, maltodextrins of dextrose equivalence (DE) 5, 20 and 45 and 10%w/w NaCl were first dissolved in water and then…
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Integrating pressure sensor control into semi-solid extrusion 3D printing to optimize medicine…
Semi-solid extrusion (SSE) is a three-dimensional printing (3DP) process that involves the extrusion of a gel or paste-like material via a syringe-based printhead to create the desired object. In pharmaceuticals, SSE 3DP has already been used to manufacture formulations for human clinical studies.…
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Influence of de-structured starch on fine-stranded polymeric and coarse-stranded particulate whey…
This study investigated the phase stability of liquid mixtures and composite gels properties of de-structured waxy potato starch (DWPS) and whey protein isolate (WPI). The DWPS are physically-modified starches treated at 120, 140 and 150 °C for 30 min under constant shear. The composite gels (13%…
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