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Mucoadhesion
Chitosan-(poly)acrylic acid polyelectrolyte complexes: Enhanced mucoadhesion and sustained drug…
Polyelectrolyte complexes (PECs) have emerged as promising vehicles for medical applications, attributable to their non-toxicity, non-immunogenicity, and ability for controlled drug release. Notably, their inherent mucoadhesive properties are being leveraged for sustained drug delivery across…
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Chitosan and Anionic Solubility Enhancer Sulfobutylether-β-Cyclodextrin-Based Nanoparticles as…
Abstract
Cataract surgery interventions are constantly increasing, particularly among adult and elderly patients. This type of surgery can lead to inflammatory states of the ocular anterior segment (AS), usually healed via postoperative treatment with dexamethasone (DEX)-containing eye drops. The…
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Recent advances in biopolymer-based mucoadhesive drug delivery systems for oral application
Oral drug delivery is a common and convenient route for administering pharmaceuticals, but it presents challenges related to drug stability, absorption, and targeted delivery. Because of their potential to address these challenges, biopolymer-based mucoadhesive drug delivery systems have received a…
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Intraoral Drug Delivery: Highly Thiolated κ-Carrageenan as Mucoadhesive Excipient
Aim: This study aims to design a novel thiolated κ-carrageenan (κ-CA-SH) and evaluate its potential as an excipient for the design of mucoadhesive drug delivery systems.
Methods: Native κ-carrageenan (κ-CA) was thiolated with phosphorous pentasulfide in sulfolane and characterized via 1H NMR,…
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Mucoadhesion matters – by Lubrizol
And so does your choice of mucoadhesive polymer.
Choose Carbopol® polymers and Noveon® polycarbophil.
Mucoadhesion is a type of bioadhesion in which two materials, at least one of which is mucosal, are held together for extended periods by interfacial forces.
To successfully achieve…
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Soluplus® promotes efficient transport of meloxicam to the central nervous system via nasal…
In our present series of experiments, we investigated the nasal applicability of the previously developed Soluplus® - Meloxicam polymeric micelle formulation. Utilizing the nasal drug investigations, moderately high mucoadhesion was experienced in nasal conditions which alongside the appropriate…
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Preparation of nanodelivery systems for oral administration of low molecular weight heparin
Low molecular weight heparins (LMWHs) are only used parenterally. They have low oral absorption and bioavailability due to their high anionic charge density, exposure to enzymatic degradation and first pass effect. The aim of this study was the development and evaluation of nanodelivery systems to…
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Quercetin Loaded Cationic Solid Lipid Nanoparticles in a Mucoadhesive In Situ Gel – A Novel…
The study aim was to develop an intravesical delivery system of quercetin for bladder cancer management in order to improve drug efficacy, attain a controlled release profile and extend the residence time inside the bladder. Either uncoated or chitosan coated quercetin-loaded solid lipid…
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Buccal films: A review of therapeutic opportunities, formulations & relevant evaluation…
The potential of the mucoadhesive film technology is hard to ignore, owing to perceived superior patient acceptability versus buccal tablets, and significant therapeutic opportunities compared to conventional oral drug delivery systems, especially for those who suffer from dysphagia. In spite of…
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Carbopol® Polymers: The Key to Unlocking Patient-Centric OTC Innovation
Did you know that as many as 40% of children have difficulty swallowing a normal-sized pill?
Formulate with patient needs in mind with Lubrizol Life Science Health’s comprehensive excipient range, including Carbopol® polymers, enabling patient-centric formulations with properties such as:…
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