Wound must be carefully treated to avoid serious infection that needs costly treatment. Method to enhance the recovery of the wound is crucial to have effective wound treatment. One of the technologies in wound treatment is transdermal patch that has the benefits of being non-invasive, easy to handle and permits constant drug dosage. In order to obtain a good controlled drug release, drug excipient needs to be investigated. Recently, natural Nanocrystal Cellulose (NCC) which can be synthesized from animal, algae, microorganism or plant has been actively used in drug delivery

system as excipient. The application of NCC is advantageous due to its large surface area, biodegradable, non-toxic and abundance source.

Conclusions

In this overview, transdermal patch shows a great potential to be further studied as drug delivery

system to deliver the active ingredient onto the targeted treatment area especially skin because it can

give constant drug release and fulfill the patient compliance since it is a non-invasive treatment. It is

easy for the patient to use the patch to treat the targeted area such as wound. Besides, other  ngredient in the patch that gives important effect on drug release and permeation is the excipient. The excipient shows positive result on controlling the drug release. Nanocrystal cellulose (NCC), a type of

polysaccharide extracted from natural source such as plant has been actively studied to be used as

excipient and from the results, it shows that NCC has great potential to be used in improving the

control of the drug release for transdermal patch application.

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