Advantages of Jelly over Liquid Formulations for Pediatrics

Abstract

Jellies for oral administration are non-flowable gelatinous preparations having a certain shape and size. This dosage form is being explored for applications for pediatric patients and other populations like geriatric and dysphagic patients. It has several advantages over liquid dosage forms in term of palatability, patient acceptance, suitability for controlled release applications and stability. Due to lack of information of several aspects of jellies for pediatrics, much more further studies are encouraged.

 

Definition of Jellies

According to the Japanese Pharmacopeia 17th edition (JP XVII) [1], jellies for oral administration are non-flowable gelatinous preparations having a certain shape and size, intended for oral administration.  e United States Pharmacopoeia does not have jellies for oral administration. Instead, it prefers to use the term ‘gel’ which is not to be ingested [2].  is is the de nition in USP: ‘Jelly (not preferred; see Gel): A semisolid dispersion of small particles or a solution of large organic molecules interpenetrated by a solution containing a gelling agent to promote sti ness.’ Jellies are usually prepared by mixing active substance(s) with suitable excipients and polymer gel base, gelatinizing and forming into a certain shape and size by a suitable method [1].

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Formulation Science & Bioavailability
Doolaanea and Bahari, J Formul Sci Bioavailab 2017, 1:1
Advantages of Jelly over Liquid Formulat
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