BASF

Abstract This chapter reviews data on 72 omeprazole (OME) formulations developed in the past 5 years. The types of OME formulations, the excipients and the methods are analyzed in depth. Data on 72 omeprazole (OME) formulations created over the last 5 years are reviewed in this chapter. A…
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Abstract Lung cancer ranks among the leading factors behind cancer-related fatalities across the globe. Erlotinib (ERT) is one of the frontline drugs used for lung cancer. However, ERT shows poor aqueous solubility, dissolution, gastrointestinal absorption, bioavailability, and therapeutic…
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Abstract Poloxamer 338 is used as versatile thermo-responsive gelling agent in topical and sub-cutaneous applications. Due to application specific needs a gel point below body or even below room temperature is required. The influence of inorganic salts and active pharmaceutical ingredients (APIs)…
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Abstract Background Ritonavir is an anti-retroviral protease inhibitor to treat HIV, AIDS infections. Methods The RN-SLNs were prepared by using hot homogenization followed ultrasonication method and optimized by using a two-factor, three-level central composte design (CCD). The independent…
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Abstract Microemulsions have been commonly used with various permeation enhancers to improve permeability through the skin. The purpose of this study was to compare the release and permeation ability of two commonly used permeation enhancers—diethylene glycol monoethyl ether (DGME) and oleyl…
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Abstract Background/Objectives: Chagas disease is a neglected tropical disease caused by infection with the parasite Trypanosoma cruzi. Benznidazole and nifurtimox are the only approved drugs for treating this condition, but their low aqueous solubility may lead to erratic bioavailability. This…
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Abstract Hypothesis Water-in-water (W/W) emulsions can be obtained when two water-soluble components are mutually immiscible. The scientific literature on W/W emulsions focuses on polymer–polymer mixtures, with only a few reports on polymer-salt systems, and no documented cases involving…
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Exciting news for ZoomLab® users interested in formulating solid dispersions: You can now evaluate the interaction of binary drug-polymer mixtures with the new “Solid Dispersion Phase Diagram” app! The new app will be available to all ZoomLab® users free of charge until March 2025, then will…
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Abstract Objectives: The current research finding suggests dissolution enhancement of nifedipine tablets using Liquid solid technique. Materials and Methods: The drug's solubility in various liquid carriers has been examined, out of which drug shows maximum solubility in PEG 400 which acts…
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Abstract Background/Objectives: A sustained-release formulation of fenofibrate while enhancing drug dissolution with minimal food effect is critical for maximizing the therapeutic benefits of fenofibrate. Therefore, this study aimed to develop an effective solid dispersion formulation of…
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