Material characterization with a V-shape compression profile on STYL’ONE NANO

In the early stages of drug development, APIs are often available in limited amount. However, scientists have to foresee the impact of compaction parameters on tablet attributes. In fact, tablet quality such as its hardness depends on several process parameters including the compression speed, pressure and profile used.

Compaction simulators, such as the STYL’One Nano, can easily explore compression dynamics and allow researchers to deeply understand their powder with only few grams of material. This avant-garde technology is key for fundamental material characterization and deep understanding of their product.

The goal of this bulletin is to dive into the V-shape compression cycle available on STYL’One Nano and to demonstrate its usefulness in powder characterization with real speed sensitivity practical examples.

Assess the compression speed sensitivity of your material with a V-shape profile

According to the Monograph 1062 from US Pharmacopeia, the V-shape profile is defined as a “linear compression and decompression phases that yield saw-tooth punch displacement–time profiles”.

This compression cycle is often used for powder characterization to ensure a constant punch speed during the  compression and decompression events. Hence, it allows to study the compression speed impact on tablet  characteristics. Speed in a range of 1 mm/s to 90 mm/s can be reached on the STYL’One Nano, allowing speed sensitivity assessment.

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See the full brochure on “Material characterization with a V-shape compression profile on STYL’ONE NANO” here (click the picture to view and download the full brochure)

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Source: MEDELPHARM brochure “Material characterization with a V-shape compression profile on STYL’ONE NANO”