Control of the Dissolution Profile of Paracetamol from Carbomer Matrix Tablets

Results of experiments on prolonged release of paracetamol from polymer matrix tablets with cross-linked poly(acrylic acid) Carbopol®Ultrez 21 as the prolonging polymer were reported. The effects of factors such astableting technology, type of alkaline agent, and ratio of Carbopol® toalkaline agent on paracetamol release kinetics were studied. It was established that matrices prepared by wet granulation had the best potential for prolonging the release. The ratio ofCarbopol®to alkaline agent and their relative amounts also enabled the drugrelease rate to be prolonged.

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