Electrospun HPMC/PEO-blend orodispersible films: how slight batch differences affect the crucial mechanical properties
Orodispersible films comprise a promising dosage form with a wide range of advantages compared to conventional formulations. The electrospinning process can significantly enhance the relevant characteristics of orodispersible films, e.g., the dissolution rate and the ease of administration. This study involved the use of two types of hydroxypropyl methylcelluloses of low molecular weight obtained from three different manufacturers as the matrix. The SEM, FTIR, RAMAN, and DSC analyses revealed comparable values for all the fabricated materials.
However, the mechanical properties of the fibers differed significantly, with electrospun Methocel E5/PEO proving to be particularly brittle. This is probably caused by the different arrangements of substituted methoxy- and hydroxypropyl groups of studied HPMCs. It is hoped that this paper will serve as an example of the extent to which slight differences between HPMC powder batches can dramatically alter the key properties of electrospun orodispersible films.
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Materials
Polyethylene oxide with a molecular weight of 100 kDa was purchased from Sigma Aldrich. Hypromellose Methocel E5 was purchased from JRS Pharma (Rosenberg, Germany); the viscosity value of aqueous 2% (w/v) solution at 20 °C was 5 mPas. Pharmacoat 606 was purchased from Shin‐Etsu Chemical (Tokyo, Japan); the viscosity value of aqueous 2% (w/v) solution at 20 °C was 6 mPas. Tylopur 605 and 606 were purchased from SE Tylose (Wiesbaden, Germany); the viscosity value of aqueous 2% (w/v) solution at 20 °C was 5 and 6 mPa s, respectively. Methoxyl content was 28–30% and a hydroxypropoxyl content of 7–12% for all the tested HPMCs. The purified water and Isopropyl alcohol were obtained from Penta chemicals (Czech Republic).
Asatiani, N., Filipová, B., Pechočiaková, M. et al. Electrospun HPMC/PEO-blend orodispersible films: how slight batch differences affect the crucial mechanical properties. Cellulose (2023). https://doi.org/10.1007/s10570-023-05137-4
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