Active ingredients in pharmaceuticals di er by their physico-chemical properties and their bioavailabil- ity therefore varies. e most frequently used and most convenient way of administration of medicines is oral, however many drugs are little soluble in water. us they are not su ciently e ective and suitable for such administration. For this reason a system of lipid based formulations (LBF) was developed. Series of formula- tions were prepared and tested in water and biorelevant media. On the basis of selection criteria, there were se- lected formulations with the best emulsi cation poten- tial, good dispersion in the environment and physical stability. Samples of structurally di erent drugs includ- ed in the Class II of the Biopharmaceutics classi cation system (BCS) were obtained, namely Griseofulvin, Glib- enclamide, Carbamazepine, Haloperidol, Itraconazol, Triclosan, Praziquantel and Rifaximin, for testing of maximal saturation in formulations prepared from com- mercially available excipients. Methods were developed for preparation of formulations, observation of emulsi-  cation and its description, determination of maximum solubility of drug samples in the respective formulation and subsequent analysis. Saturation of formulations with drugs showed that formulations 80 % XA and 20 % Xh, 35% XF and 65% Xh were best able to dissolve the drugs which supports the hypothesis that it is desirable to identify limited series of formulations which could be generally applied for this purpose.