Methods

Particle shape was altered through a combination of wet milling and temperature cycling. Image analysis was used to measure the length and width of the needle shaped particles. Powder handling was quantified using shear cell and bulk density measurements. Roller compaction trials were used to demonstrate improvements in processability.

Results

Particle width and length could be altered independently of each other with appropriate application of wet milling and temperature cycling. Powder handling metrics were greatly improved by the shape alteration. A partial least square model was developed to help explain the link between particle properties and powder handling metrics.

Conclusions

A process for altering the shape of needle shaped particles was developed. This process manifested in an improvement in both powder handling metrics and the processability of the powder as demonstrated by roller compaction.

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