Trends in the production methods of orodispersible films
Interest in orodispersible films (ODF) is growing day-by-day, since this dosage form overcomes some therapeutic obstacles, such as impaired swallowing, and offers several benefits, such as the possibility to adapt the dosing requirements for a subset of patients. As a consequence, technologies to produce ODF have risen attention for possible applications in the development of patient-centric formulations. This review critically discusses current trends in the technology platforms proposed to the production of ODF, including the innovation and opportunities to produce very small batches in a pharmacy setting.
Although the main Pharmacopoeias recommend testing customized dosage forms for quality assurance, pharmaceutical assays are a matter of debate due to the complexity and high cost of conventional methods. Alternatively, non-disruptive online analytic methods can be proposed to assay ODF properties, above all to assure the uniformity of drug content.
Article Information: Author links open overlay panelUmberto M. Musazzi, Garba M. Khalid, Francesca Selmin, Paola Minghetti, Francesco Cilurzo; Sciencedirect, 2019.
Umberto M. Musazzi, Garba M. Khalid, Francesca Selmin, Paola Minghetti, Francesco Cilurzo, Trends in the production methods of orodispersible films, International Journal of Pharmaceutics, Volume 576, 2020, 118963, ISSN 0378-5173, https://doi.org/10.1016/j.ijpharm.2019.118963.