Are you facing the challenge of replacing TiO₂ in your coating formulations? Get one of the limited sample boxes!

For decades, titanium dioxide (TiO₂) has been used as a white pigment due to its very high opacity and brightness. Therefore, it has a wide range of applications, from being a coloring ingredient of pharmaceutical film coating, to food application coloring.

Titanium dioxide free film coatings

Based on current discussions about a new classification and labelling of TiO₂ and the re-evaluation of TiO₂ (E171) as a non save considered food additive in the EU by EFSA, BIOGRUND is committed to offering alternatives for common film coating formulations. To address this issue, BIOGRUND has developed alternatives to replace titanium dioxide in existing film coating systems.

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tablets without tio2 — Tablets without TiO2

AquaPolish^®, formulated without TiO₂, provides a comparable white film coating for oral solid dosage forms. Differences to the use of titanium dioxide are not apparent to the eye. The opacity is similar even when used on dark tablet cores.

If required, colored film coating systems can be developed or replaced by a TiO₂-free version. According to customer requirements, light-stable natural pigments can be used in the formulation when synthetic colors and iron oxides are not allowed.

Titanium dioxide free tablet film coating with strong whitening and opacifying properties? Why not!

This sample box presents an alternative to TiO2 as a white pigment in tablet film coating. It shows a comparison of the opacity of conventional Aqua-Polish^® white coating (with TiO2) and our new AquaPolish^®, formulated without TiO2, after a 100 kg and 300 kg production scale. The opacity measurement according to the CIELAB method resulted in the following values (maximum is L100):

Brown placebo: L65
with TiO2 (100 kg): L97
TiO2 free (100 kg): L95

Film coating without TiO2 has always been a challenge. Not only the choice of the appropriate coating formulation is crucial for a successful coating, but also the adaptation of the process parameters to the coating, tablets and machine. With our technical support we accompany your trials and assist you in setting the right parameters for excellent results.

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