Scaling Tableting Processes from Compaction Simulator to Rotary Presses—Mind the Sub-Processes

1. April 2020

Compaction simulators are frequently used in the formulation and process development of tablets, bringing about the advantages of flexibility, low...

Evolution of the microstructure and the drug release upon annealing the drug loaded lipid-surfactant microspheres

10. March 2020

The present study investigates the drug release-governing microstructural properties of melt spray congealed microspheres encapsulating the drug crystals in the...

Development of sustained release tablets with Compritol 888 ATO

Developing sustained release tablets with Compritol® 888 ATO

3. March 2020

Compritol® 888 ATO is a fine white powder, insoluble in water and organic solvents. It has no odor and no...

Hot-melt extruded lipidic pellets for pediatric applications: An investigation of the effects and stability on drug dissolution

24. February 2020

The current study investigates the development of extemporaneous preparation of hot melt extruded diclofenac sodium (Df-Na) pellets processed with glyceryl...

Comparison of two encapsulation processes to protect the commensal gut probiotic bacterium Faecalibacterium prausnitzii from the digestive tract

23. February 2020

Anaerobic commensal gut bacteria are among the most promising future treatments for many diseases. Because of their sensitivity to oxygen...

Evaluation Of Self-Emulsifying Drug Delivery Systems For Oral Insulin Delivery Using An In Vitro Model Simulating The Intestinal Proteolysis

23. February 2020

The gentle preparation and the functionalization potential of self-emulsifying drug delivery systems (SEDDS) make them an interesting formulation strategy for...

Tableting of hot-melt coated paracetamol granules: Material tableting properties and quality characteristics of the obtained tablets

22. February 2020

Hot-melt coating (HMC) has been recognized as a promising technique in the production of solid dosage forms e.g., HMC of...

Novel approach for overcoming the stability challenges of lipid-based excipients. Part 1: Screening of solid-state and physical properties of polyglycerol esters of fatty acids as advanced pharmaceutical excipients

20. February 2020

The major challenge of conventional lipid-based excipients (LBE) for drug delivery is their unstable solid state, affecting the stability of...

Systematic implementation of quality-by-design (QbD) to develop NSAID-loaded nanostructured lipid carriers for ocular application: preformulation screening studies and statistical hybrid-design for optimization of variables

19. February 2020

The objective of the present project was to develop and optimize the Ibuprofen (IBU)-loaded nanostructured lipid carrier (IBU-NLCs) for sustained-release...

Nanostructured lipid carrier co-delivering tacrolimus and TNF-α siRNA as an innovate approach to psoriasis

19. February 2020

Since psoriasis is an immuno-mediated skin disease, long-term therapies are necessary for its treatment. In clinical investigations, tacrolimus (TAC), a...

Oleochemicals