Oils have been used by the pharmaceutical industry for decades. From parenteral nutrition to soft gel formulations, oils play a key role in a wide range of pharmaceutical products. With an ever increasing number of new drug candidates with poor aqueous solubility and poor oral bioavailability, oils are very attractive candidates to solve real challenges for the formulators.
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Pharmaceutical Oils
Processing of Lipid Nanodispersions into Solid Powders by Spray Drying
Spray drying is a promising technology for drying lipid nanodispersions. These formulations can serve as carrier systems for poorly water-soluble active pharmaceutical ingredients (APIs) that are loaded into the lipid matrix to improve their bioavailability. Once the API-loaded nanocarriers have…
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Design And Optimization of Midazolam Loaded Microemulsion Using Quality by Design (Qbd) Assisted…
Abstract
Introduction: More emphasize was given in the present work is application of QbD tools and DoE approach. The existing study was aimed towards development and characterization of Midazolam (MZM) loaded microemulsion (ME) for brain delivery through nasal route.
Methods: Different QTPP and…
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Use of high melting point solid vegetable oils in encapsulation processes – ADM White Paper
Use of high melting point solid vegetable oils in encapsulation processes
Introduction to encapsulation
Encapsulation relates to technologies that enable the incorporation of a compound into individualized small
particles. Depending on the process applied, these particles can have…
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Hypromellose – Collagen hydrogels/sesame oil organogel based bigels as controlled drug delivery…
The search for novel strategies to formulate bioactive molecules for topical administration is a matter of permanent interest in the pharmaceutical field. As a contribution, the present work deepens the bigels, i.e., matrix-in-matrix systems resulting from mixing a hydrogel and an organogel.…
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Lipid based excipients by IOI Oleo – Overview brochure
For lipid-based excipients and active pharmaceutical ingredients “Made in Germany” – you can rely on IOI Oleo.
Decades of experience and expertise shape today’s quality of our specialty products and drive new product developments and operational excellence.
As a result, IOI Oleo brand names are…
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Tamoxifen Citrate Containing Topical Nanoemulgel Prepared by Ultrasonication Technique: Formulation…
The present study aims to design and develop a nanoemulgel formulation of Tamoxifen citrate (TAM), a water-insoluble, potent anticancer drug, using the spontaneous emulsification method to improve topical delivery, achieve high accumulation at the tumour site, and spare the healthy tissues. The…
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Production, physicochemical investigations, antioxidant effect, and cellular uptake in Caco-2 cells…
The purpose of this study was to develop astaxanthin (AST)-loaded self-microemulsifying drug delivery system (SMEDDS) tablets and evaluate their physicochemical and biological properties. The optimized liquid (L)-AST SMEDDS formulation was composed of rice bran oil (33.67%), Kolliphor® RH 40…
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Standardization of an in vitro assay matrix to assess cytotoxicity of organic nanocarriers: a pilot…
Nanotechnologies such as nanoparticles are established components of new medical devices and pharmaceuticals. The use and distribution of these materials increases the requirement for standardized evaluation of possible adverse effects, starting with a general cytotoxicity screening. The Horizon…
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Nanoemulsion for delivery of anticancer drugs
Cancer refers to a collection of diseases that have abnormal cell growth as their hallmark. This inability of cytotoxic agents to distinguish between rapidly dividing healthy cells andrapidly multiplying cancerous cells produces the most notorious adverse effects of cytotoxicanticancer agents. As an…
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Combining lipid based drug delivery and amorphous solid dispersions for improved oral drug…
Two widely applied enabling drug delivery approaches, self-nanoemulsifying drug delivery systems (SNEDDS) and amorphous solid dispersions (ASD), were combined, with the aim of enhancing physical stability, solubilization and absorption of the model drug ritonavir. Ritonavir was loaded at a…
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