Oral Excipients

Experience the future of Titanium Dioxide (TiO2) replacement! Discover bright white films and brilliant colors at reasonable weight gains even on your darkest tablet cores! Enjoy the freedom of choice when banning TiO2 from your tablet coatings: TiO2 -free                             Low…
Read More...

This poster was presented at CRS 2024 in Bologna Introduction The aim of this study was to develop and implement a PBBM to predict the human PK behavior of an orally administered BCS IV drug (compound X) under fasted conditions. The advanced tiny-TIMsg gastrointestinal model, part of the SurroGUT…
Read More...

Abstract Background: Due to its simplicity and cost-effectiveness, direct compression has become the approach most frequently used to create tablet. Nonetheless, the active pharmaceutical ingredient should have acceptable flow and good compaction qualities in order to use direct compression in…
Read More...

Abstract Repaglinide (RPG) belongs to the class of drugs known as meglitinides and is used for improving and maintaining glycemic control in the treatment of patients with Type 2 diabetes. RPG is a Class II drug (BCS) because of its high permeability and low water solubility. It also undergoes…
Read More...

In this study, a compartmental disintegration and dissolution model is proposed for the prediction and evaluation of the dissolution performance of directly compressed tablets. This dissolution model uses three compartments (Bound, Disintegrated, and Dissolved) to describe the state of each particle…
Read More...

Abstract Clobetasol-17-proprionate (CP) is the most potent, highly lipophilic topical corticosteroid, used for the treatment of immune-mediated muco-cutaneous diseases. No commercial preparations are available for oral cavity and galenic formulations are often ineffective due to the easy…
Read More...

Softgel capsules are a popular choice for delivering a wide range of compounds, from pharmaceuticals to nutritional supplements. Their versatility and efficacy hinge on the type of fill material used. Let's explore the three primary types of fills for softgel capsules: Single Oil or Oil Mixtures,…
Read More...

Local drug delivery to the esophagus is hampered by rapid transit time and poor permeability of the mucosa. If some strategies aimed to improve the residence time have been proposed, non-invasive approaches to increase the drug penetration in the mucosa have not been described so far. Herein, we…
Read More...

Abstract A promising solution to customize oral drug formulations for the pediatric population has been found in the use of 3D printing, in particular Fused Deposition Modeling (FDM) and Semi-Solid Extrusion (SSE). Although formulation development is currently limited to research studies, the…
Read More...

Soft Gelatin Capsules (SGCs), commonly known as softgels, have transformed drug delivery since their invention. Despite their 19th-century origins, their widespread adoption only began in the 20th century, thanks to technological advancements by Robert Pauli Scherer. This innovation revolutionized…
Read More...