Oral Excipients

Abstract Background: Propranolol, largely prescribed as an antihypertensive and antiarrhythmic drug in pediatrics, is characterized by a bitter taste and an astringent aftertaste. Currently, the therapy requires crushing of tablets for adults and their dispersion in water many times a day, leading…
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Abstract Curcumin, a bioactive compound derived from turmeric, possesses numerous pharmaceutical properties; however, its poor aqueous solubility and permeability result in low bioavailability. This study aims to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) using different…
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Abstract MUPS (multiple unit particle systems) are oral dosage forms consisting of small particles which are filled into capsules or compressed into tablets. Compared to monolithic sustained-release tablets, MUPS tablets rapidly disintegrate inside the stomach releasing the contained small…
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Abstract Acetaminophen is a commonly used drug for its main analgesic and antipyretic properties. This study was designed to detect organic volatile impurities in different acetaminophen formulations on the market. The study also aimed at developing and optimizing a headspace gas chromatography…
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Abstract Optical coherence tomography (OCT) has emerged as an in-line monitoring technique for pharmaceutical coating processes based on a representative number of samples. In this study, an approach was developed to correlate the coating thickness measured in-line via OCT with the resultant…
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Abstract Gastrointestinal disorders originate in the gastrointestinal tract (GIT), and the therapies can benefit from direct access to the GIT achievable through the oral route. RNA molecules show great promise therapeutically but are highly susceptible to degradation and often require a carrier…
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Developing a formulation for the oral route is a long and complex journey in which the API (Active Pharmaceutical Ingredient) characteristics are of an utmost importance. Amidon et al. were the first, in 1995, to suggest a classification system for APIs, in which they correlated in vitro drug…
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From optimized gastric resistance to enhanced bioavailability - EUDRACAP® leverages the functional versatility and safety of EUDRAGIT® to solve key challenges in oral drug delivery. Pharmaceutical companies launching new oral drugs need the right coated capsule formulation to enhance performance…
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Abstract Purpose of review Herein, we present an overview of innovative oral technologies utilized in colonic drug delivery systems that have made significant translational and clinical advancements to treat inflammatory bowel disease (IBD) in recent years. Recent findings The colon is home to…
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Press Release Health Care, Essen, Germany, September 25, 2024 EUDRACAP® colon is the only functional, ready-to-fill capsule on the market targeting the ileo-colonic region New capsule is available in technical grade with a GMP product in development Further builds Evonik’s platform…
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