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Trehalose
Formulation of antiretroviral nanocrystals and development into a microneedle delivery system for…
HIV/AIDS remains a major global public health issue. While antiretroviral therapy is effective at reducing the viral load in the blood, up to 50% of those with HIV suffer from some degree of HIV-associated neurocognitive disorder, due to the presence of the blood-brain barrier restricting drugs from…
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Tableting of fluidized bed granules containing living microorganisms
Tablets are the favored dosage form for numerous active pharmaceutical ingredients, among others because they are easy to take, ensure safe dosing and allow cost-effective production on a large scale. This dosage form is also frequently chosen for the administration of viable probiotic …
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Impact of matrices composition and processes on β-galactosidase encapsulation
Advances in existing drying techniques are essential for upgrading large scale industries. Enzymes are often degraded by drying processes. Spray drying (SD) has detrimental effects on bioactive molecules at high temperatures. Freeze-drying (FD) is a reference technique capable of drying sensible…
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Impact of Different Saccharides on the In-Process Stability of a Protein Drug During Evaporative…
Objectives
Solid biopharmaceutical products can circumvent lower temperature storage and transport and increase remote access with lower carbon emissions and energy consumption. Saccharides are known stabilizers in a solid protein produced via lyophilization and spray drying (SD). Thus, it is…
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Maintaining supersaturation generation and protein integrity of amorphous curcumin-albumin nanoplex…
Amorphous curcumin-albumin nanoplex (size ≈ 100 nm, 55 wt% curcumin content) is a highly promising nanoscale delivery system of curcumin attributed to its high curcumin's payload and kinetic solubility. Its storage stability, however, has not been established. Previously, freeze-dried nanoplex with…
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Transforming monomeric globulins into pickering particles to stabilize nanoemulsions: Contribution…
Monomeric globulins have been widely employed in food-grade nanoemulsion preparation owing to their outstanding emulsification performance. However, a limitation to stabilize nanoemulsions during storage exists when using monomeric globulin as sole emulsifier, mainly due to the low structural…
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Lyophilization for Formulation Optimization of Drug-Loaded Thermoresponsive Polyelectrolyte Complex…
The lyophilization of nanogels is practical not only for their long-term conservation but also for adjusting their concentration and dispersant type during reconstitution for different applications. However, lyophilization strategies must be adapted to each kind of nanoformulation in order to…
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Effect of Process Parameters, Protectants and Carrier Materials on the Survival of Yeast Cells…
The administration of living microorganisms is of special interest, with regard to probiotic microorganisms providing health benefits to the patient. Effective dosage forms require the preservation of microbial viability until administration. Storage stability can be improved by drying, and the…
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Alternative Excipients for Protein Stabilization in Protein Therapeutics: Overcoming the Limitations…
Given their safety and efficiency in protecting protein integrity, polysorbates (PSs) have been the most widely used excipients for the stabilization of protein therapeutics for years. In recent decades, however, there have been numerous reports about visible or sub-visible particles in…
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Trehalose in Biomedical Cryopreservation–Properties, Mechanisms, Delivery Methods, Applications,…
Cells and tissues are the foundation of translational medicine. At present, one of the main technological obstacles is their preservation for long-term usage while maintaining adequate viability and function. Optimized storage techniques must be developed to make them safer to use in the clinic.…
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