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Trehalose
Live Biotherapeutics: importance of formulation and lyophilization parametersand an example of a…
In recent years, probiotics have expanded from their traditional classification as “health promoting food” to the development of live biotherapeutic products (LBP). Traditional probiotics are marketed as food/dietary supplements while LBPs are drug products intended for treatment or prevention of…
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Nanoparticulate impurities in the pharmaceutical excipient trehalose induce an early immune response
Abstract
Background
Pharmaceutical excipients are an important part of biological products. However, few attempts have been made to distinguish between the risk of inflammation associated with the biological products themselves and that associated with excipients. The analysis of early immune…
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A Comprehensive Scientific Survey of Excipients Used in Currently Marketed, Therapeutic Biological…
Purpose
The steady development of biotechnology-derived therapeutic biologics over the last few decades has generated drugs that are now standard medical treatments for a range of indications. While the development of protein products has surged in recent years, the formulation and delivery of…
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Formulation of antiretroviral nanocrystals and development into a microneedle delivery system for…
HIV/AIDS remains a major global public health issue. While antiretroviral therapy is effective at reducing the viral load in the blood, up to 50% of those with HIV suffer from some degree of HIV-associated neurocognitive disorder, due to the presence of the blood–brain barrier restricting drugs from…
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Deciphering the Structure-Property Relationship and Antioxidant Mechanisms of Trehalose – An…
Reactive Oxygen Species (ROS) have attracted significant attention among researchers as they play a role in cell death when produced excessively. To address this issue, scientists are actively seeking suitable antioxidants that can counteract the effects of ROS. Trehalose, a disaccharide molecule…
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A systematic review of commercial high concentration antibody drug products approved in the US:…
Three critical aspects that define high concentration antibody products (HCAPs) are as follows: 1) formulation composition, 2) dosage form, and 3) primary packaging configuration. HCAPs have become successful in the therapeutic sector due to their unique advantage of allowing subcutaneous…
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Ranking mAb–excipient interactions in biologics formulations by NMR spectroscopy and computational…
ABSTRACT
Excipients are added to biopharmaceutical formulations to enhance protein stability and enable the development of robust formulations with acceptable physicochemical properties, but the mechanism by which they confer stability is not fully understood. Here, we aimed to elucidate the…
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High resveratrol-loaded microcapsules with trehalose and OSA starch as the wall materials:…
To improve the solubility and stability of resveratrol (Res), Res nanocrystals (Res-ncs) as the capsule core were prepared by wet milling using hydroxypropyl methyl cellulose (HPMCE5), sodium dodecyl sulfate (SDS), and polyvinylpyrrolidone (PVPK30) as stabilizers, along with trehalose and octenyl…
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Bulk Flow Optimisation of Amorphous Solid Dispersion Excipient Powders through Surface Modification
Particulate amorphous solid dispersions (ASDs) have been recognised for their potential to enhance the performance of various solid dose forms, especially oral bioavailability and macromolecule stability. However, the inherent nature of spray-dried ASDs leads to their surface cohesion/adhesion,…
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A smart solution for Biopharmaceutical Development – by Hayashibara
TREHALOSE SG JP, USP-NF, Ph. Eur., CP
High-purity and low endotoxin injectable grade trehalose
TREHALOSE SG is an injectable grade pharmaceutical excipient and is monographed as being low endotoxin and high purity. It is supplied as powdered dihydrate crystals produced by the enzymatic…
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