Parenteral Excipients

Abstract Thiolated polymers, or thiomers, are a class of polymers that exhibit unique mucoadhesive properties, allowing them to form strong covalent bonds with cysteine-rich subdomains of mucus glycoproteins. This property makes them ideal for developing drug delivery systems (DDSs) for various dry…
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Three critical aspects that define high concentration antibody products (HCAPs) are as follows: 1) formulation composition, 2) dosage form, and 3) primary packaging configuration. HCAPs have become successful in the therapeutic sector due to their unique advantage of allowing subcutaneous…
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THE IMPORTANCE OF PARENTERAL DRUGS Parenteral drugs are infused or injected either intravenously, intramuscularly, or subcutaneously into the body to treat a wide range of diseases and conditions. Injectables are the second fastest growing segment in the drug delivery technology market and are…
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Single-use components, excipients, filters and validation services Reduce risk and increase efficiency with a fully assembled ready-to-use system: • Let us help you design a process to meet your specific needs. • What are the risks you are facing? • What are your set-up and system issues to…
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Abstract The management of chronic conditions often requires patients to take daily medication for an extended duration. However, the need for daily dosing can lead to nonadherence to the therapy, which can result in the recurrence of the disease. Long-acting parenteral drug delivery systems have…
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TREHALOSE SG JP, USP-NF, Ph. Eur., CP High-purity and low endotoxin injectable grade trehalose TREHALOSE SG is an injectable grade pharmaceutical excipient and is monographed as being low endotoxin and high purity. It is supplied as powdered dihydrate crystals produced by the enzymatic…
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ATTRIBUTES OF EXCIPIENTS FOR HIGH-RISK FORMULATIONS Excipients play an important role in parenteral formulations, which are high-risk given their route of administration. They protect, support, and enhance stability and bioavailability, modulate release of the API, and can enhance effectiveness of…
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Don’t let poor solubility affect your innovative drug projects Approximately 60% of potential active pharmaceutical ingredients (APIs) under development, and more than 40% of those in reformulation, are poorly water soluble1. Solubility challenges present a substantial hurdle to the development…
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While the global market for veterinary products has been expanding rapidly, there is still a lack of specialist knowledge of equine pharmaceutics. In many cases, the basic structure of the gastrointestinal tract (GIT) and integumentary system of the horse shares similarities with those of humans.…
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The pharmaceutical industry has two main ways to generate new products. The first option is to look for new drug substances. A second option is to employ better formulations of an existing drug product. Such reformulated products are called Pharmaceutical Form Line Extensions. As part of such a…
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