Plasticizer

Abstract Orodispersible films (ODFs) are thin, mechanically strong, and flexible polymeric films that are designed to dissolve or disintegrate rapidly in the oral cavity for local and/or systemic drug delivery. This review examines various aspects of ODFs and their potential as a drug delivery…
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The objective of this work was to formulate zingiberine as medicated chewing gum for improving its bioavailability. The objective was achieved by isolating zingiberine form ginger oil and formulating chewing gum using zein as the gum base by melting method. The formulation of ZCGs was achieved using…
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See the new book, edited by Michael A. Repka, Nigel Langley Covers regulatory and manufacturing aspects of 3D printing in drug development Particular focus on hot melt extrusion and extruded filaments suitable for optimizing 3D printing Thorough short text and guide for use on the…
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The research work aimed to develop a robust sustained release biocompatible brinzolamide (BRZ)-loaded ocular inserts (MeltSerts) using hot-melt extrusion technology with enhanced solubility for glaucoma management. A 32 rotatable central composite design was employed for the optimization of the…
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Abstract Background: Enteric coating films in acidic labile tablets protect the drug molecule from the acidic environment of the stomach. However, variations in the excipients used in the coating formulation may affect their ability to provide adequate protection. This study is the first to…
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Soft gelatin capsules are the most widely used pharmaceutical form after tablets. The active components, active pharmaceutical ingredients or nutrients are dissolved or suspended in a liquid or semi-solid fill, which is covered with a gelatin shell. Several factors can modify the properties of the…
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This study proposes the application of carboxymethyl starch derivatives as tablet coatings affording gastro-protection. Carboxymethyl starch (CMS) films were obtained by casting of aqueous filmogenic starch solutions with or without plasticizers and their structural organization was followed using…
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Hydrochlorothiazide (HTZ) is a potent thiazide diuretic that is used in the management of hypertension. However, HTZ suffers from low and variable oral bioavailability owing to its poor dissolution and limited intestinal permeability. Thus, the aim of this study was to enhance the dissolution…
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Did you know that based on the virtual tool BitterPredict, about 40% of random molecules, 66% of clinical and experimental drugs, and almost 77% of natural products are bitter1? This leads us to concern about the final formulation's palatability and look for alternatives to overcome the…
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How can plasticizers impact the functionality of film-coating latex-based dispersion? When formulating a film coating, plasticizers are often required to increase polymer chain mobility, improve mechanical properties, such as elasticity and cracking resistance, and reduce the minimum film…
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